G
Gerald E. Adams
Researcher at University of Manchester
Publications - 52
Citations - 1122
Gerald E. Adams is an academic researcher from University of Manchester. The author has contributed to research in topics: Radical & Alkyl. The author has an hindex of 19, co-authored 52 publications receiving 1117 citations.
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Mechanism of tryptophan oxidation by some inorganic radical-anions: a pulse radiolysis study
TL;DR: The experimental data are in accord with the model and enable the equilibrium constants of the reactions to be obtained, and a kinetic model for the ( SCN)–2/TrpH reaction predicts a variation of the equilibrium concentration of (SCN)-2 with [H+], [trpH] and [SCN–].
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RSU 1069, a nitroimidazole containing an aziridine group
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RSU 1069, a nitroimidazole containing an aziridine group. Bioreduction greatly increases cytotoxicity under hypoxic conditions.
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Bioreductive drugs for cancer therapy: The search for tumor specificity☆
Gerald E. Adams,Ian J. Stratford +1 more
TL;DR: The concept of potentiating bioreductive drug activity by increasing tumor hypoxia by the use of photodynamic therapy (PDT) in combination with RSU-1069 and changes in expression of reductase enzyme levels are considered in the context of the heterogenous nature of the tumor microenvironment.
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Indolequinone Antitumor Agents: Reductive Activation and Elimination from (5-Methoxy-1-methyl-4,7-dioxoindol-3-yl)methyl Derivatives and Hypoxia-Selective Cytotoxicity in Vitro
Matthew A. Naylor,Elizabeth Swann,Steven Albert Everett,Mohammed Jaffar,John Nolan,N Robertson,S D Lockyer,Kantilal B. Patel,Madeleine F. Dennis,Michael R.L. Stratford,Peter Wardman,Gerald E. Adams,Christopher J. Moody,Ian J. Stratford +13 more
TL;DR: A series of indolequinones bearing a variety of leaving groups at the (indol-3-yl)methyl position was synthesized by functionalization of the corresponding 3-(hydroxymethyl)indolequinone, and the resulting compounds were evaluated in vitro as bioreductively activated cytotoxins.