Objective To determine the clinical and laboratory features of newly diagnosed multiple myeloma. Patients and Methods Records of all patients in whom multiple myeloma was initially diagnosed at the Mayo Clinic in Rochester, Minn, from January 1, 1985, to December 31, 1998, were reviewed. Results Of the 1027 study patients, 2% were younger than 40 years, and 38% were 70 years or older. The median age was 66 years. Anemia was present initially in 73% of patients, hypercalcemia (calcium level ≥11 mg/dL) in 13%, and a serum creatinine level of 2 mg/dL or more in 19%. The β2-microglobulin level was increased in 75%. Serum protein electrophoresis revealed a localized band in 82% of patients, and immunoelectrophoresis or immunofixation showed a monoclonal protein in 93%. A monoclonal light chain was found in the urine in 78%. Nonsecretory myeloma was recognized in 3% of patients, whereas light-chain myeloma was present in 20%. Conventional radiographs showed an abnormality in 79%. The plasma cell labeling index was 1% or more in 34% of patients. Multivariate analysis revealed that age, plasma cell labeling index, low platelet count, serum albumin value, and the log of the creatinine value were the most important prognostic factors. Conclusion The median duration of survival was 33 months and did not improve from 1985 through 1998.

Review of 1027 Patients With Newly Diagnosed Multiple Myeloma

Hapten-Induced Model of Chronic Inflammation and Ulceration in the Rat Colon

HIF-1α Is Essential for Myeloid Cell-Mediated Inflammation

https://www.gastrojournal.org/article/0016-5085(84)90202-6/pdf

Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity: Assessment of inflammation in rat and hamster models

Necrotizing enterocolitis: treatment based on staging criteria.

Measurement of Cutaneous Inflammation: Estimation of Neutrophil Content with an Enzyme Marker

Cellular and Extracellular Myeloperoxidase in Pyogenic Inflammation

Exhaustion of mature marrow neutrophils in neonates with sepsis

We measured the effect of lithium on the blood neutrophil mass and neutrophil production, using standard di-isopropylfluorophosphate (DF32P) methods. In 12 lithium-treated patients the total blood neutrophil pool was 105 (42 to 270) X 107 cells per kilogram (median and 95 per cent limits) as compared with 61 (27 to 138) X 107 in 71 controls (P<0.001). The neutrophil turnover rate, a measure of effective neutrophil production, was 230 (108 to 380) X 107 cells per kilogram per day in the lithium-treated group and 160 (62 to 400) X 107 in the controls (P<0.05). Neutrophil migration into skin lesions ranged from 34 to 469 X 105 cells per day in the lithium-treated patients, as compared with 1.7 to 68 X 105 in 10 controls. Lithium causes enlargement of the total circulating neutrophil mass and accelerates neutrophil production without impairing neutrophil migration into skin lesions. (N Engl J Med 298:178–180, 1978)

Effect of Lithium on Neutrophil Mass and Production

During a three-year period, 26 neonates with bacterial infection and neutropenia were studied. In order to assess the marrow neutrophil reserves, bone marrow aspirates were obtained from each of these patients. The neutrophil storage pool (percent polymorphonuclear + band neutrophils + metamyelocytes in 1,000 nucleated marrow cells) was significantly greater in those who survived their infection (X= 20.1%, range 3.2% to 60.8%) than in those who died (X = 1.9%, range 0.4% to 5.2%, P P

Gerald Rothstein

Papers

Measurement of Cutaneous Inflammation: Estimation of Neutrophil Content with an Enzyme Marker

Cellular and Extracellular Myeloperoxidase in Pyogenic Inflammation

Exhaustion of mature marrow neutrophils in neonates with sepsis

Effect of Lithium on Neutrophil Mass and Production

Granulocyte Transfusions in Neonates with Bacterial Infection, Neutropenia, and Depletion of Mature Marrow Neutrophils