Showing papers in "Journal of Investigative Dermatology in 1982"

TL;DR: It is demonstrated that MPO can be used as a marker for skin neutrophil content: it is recoverable from skin in soluble form, and is directly related to neutrophIL number.

TL;DR: It is demonstrated that epidermal cells do move over a fibrin and fibronectin matrix during in vivo wound repair, as well as other factors regulating the attachment and directional migration of a regenerating epidermis in wound healing.

TL;DR: It is proposed that one of the features of cutaneous aging is a slow, spontaneous, progressive degradative process inherent in the elastic fiber that can be enzymatically accelerated from decades to hours by elastase and chymotrypsin.

TL;DR: The data indicate that epidermal cells, devoid of Langerhans cells, are capable of producing factors with IL-1 like activity and may thereby modulate immune responses locally in the skin and perhaps systemically.

TL;DR: A surprising histologic finding was the repair capability of the dermis in the post-irradiation period of hairless mice, which showed a great increase in the reticulin fibers, elastic fibers to the extent of elastosis, neutral and acid mucopolysaccharides and melanin production.

TL;DR: It is suggested that fibronectin may provide a provisional substratum for endothelial cell mitosis and movement in blood vessel walls as well as in granulation tissue secondary to a brightly fluorescent reticular background staining.

TL;DR: UV-induced LC changes appear qualitatively similar in young and old adults and include histological evidence of cellular damage, transient association of LC with damaged keratinocytes, and possible migration of LC from the irradiated epidermis within 24 hr.

TL;DR: The observations indicate that cellular degeneration and the generation of debris in vitiligo are not limited to melanocytes but include keratinocytes and probably whole epidermal melanin units, and the fine structure of the epidermis in normal-appearing skin is markedly altered by the disease process in patients with Vitiligo.

TL;DR: Serial biopsies from 6 patients support the concept that the initiating factors in psoriasis are in the epidermis, but epidermal hyperplasia cannot occur without vascular proliferation.

TL;DR: Elastinolytic enzymes are found in microorganisms, snake venoms, and in a number of mammalian cells and tissues, including pancreas, polymorphonuclear leukocytes, and macrophages, and show a spectrum of different specificities.

TL;DR: Although all these peroxides were inactive either as initiators or as complete carcinogens, lauroyl peroxide was as effective as benzoyl peroxide when used as a skin tumor promoter in a two-stage carcinogenesis protocol, and hydrogen peroxide proved to be a very weak skin tumors promoter.

TL;DR: The viscoelastic nature of the skin shows that a simple structural model based only on collagen and elastin is not adequate for a full understanding of this tissue.

TL;DR: The observations support an hypothesis that alterations in one component of the connective tissue matrix may influence the deposition and structure of others, ultimately, modifying the overall organization and mechanical properties of the tissue.

TL;DR: The sequence of histopathologic events in the pathogenesis of bullous pemphigoid includes mast cell granule alterations and release of granule contents from eosinophils which are undergoing nuclear and cytoplasmic damage.

TL;DR: The superficial horny layer of normal skin is much less hygroscopic and less capable of holding water than the corresponding deeper portions and scaly skin shows functional defects in both hygroScopicity and water-holding capacity, between which the former normalizes much faster than the latter.

TL;DR: In this study, in vitro evidence directly supporting a functional role for immune-complex mediated inflammation in the pathogenesis of basement membrane zone separation and blisters in bullous pemphigoid is provided.

TL;DR: Progress has been made in identifying and characterizing basement membrane macromolecules, including type IV collagen, laminin, a heparan sulfate proteoglycan and bullous pemphigoid antigen, which are found in certain basement membranes, mostly those of stratified squamous epithelia.

TL;DR: Results provide direct evidence that stratum corneum cell membrane regions are preferentially enriched in lipids over whole tissue, confirming earlier morphological studies that lipids are progressively segregated in membrane domains during cornification.

TL;DR: Results showed that the interindividual differences were larger for carotene and dehydroretinol than for retinol, whereas the intraindividual variations were larger by comparison with age and sex.

TL;DR: The ultrastructural studies confirm the specificity of OKT6 for Langerhans cells and suggest that the indeterminate cell represents a related cell population.

TL;DR: The data suggest that with advancing age the sunburn reaction is quantitatively reduced and evolves more slowly following a standardize ultraviolet exposure.

TL;DR: Dried skin, when appropriately rehydrated before use, exhibits rates of drug permeation similar to those found with fresh skin, as compared with frozen samples of excised skin.

TL;DR: A stepwise building up of carbohydrates with blood group specificities during the differentiation of buccal epithelial cells, suggest a stepwise build-up of carbohydrates in the form of N-acetyl-lactosamine and lacto-N-triosyl.

TL;DR: The structure of a normal dermis is described without demonstrating the range of normal in any one of its elements, as well as Reference will occasionally be made to abnormal conditions of the matrix since through these deviations it is possible to understand more about the normal.

TL;DR: HPV 1-induced lesions represented typical myrmecia warts, varying in the number and shape of inclusion bodies, while HPV 1 and HPV 2 induced warts was more heterogenous.

TL;DR: It is proposed that the veil cell is responsible for the synthesis and maintenance of the peripheral portion of the vascular wall of the dermal microcirculatory vessels and with progressive aging there is a decrease in the number and synthetic activity of veil cells which correlates with the appearance of abnormally thin walled vessels.

TL;DR: Electrical stimulation of hairy skin with response patterns obtained from individual cat polymodal nociceptive neurons to pain- and itch-producing stimuli caused no differences in the quality of the evoked pruritic sensations, and the idea that the same population of primary sensory neurons can produce both itch and pain by changing their pattern of discharge is rejected.

TL;DR: It is concluded that in normal SC the extractable lipids are intimately involved in cellular adhesion/dyshesion and in barrier formation.

TL;DR: A recently described immunofluorescence mounting buffer containing para-phenylenediamine prevents fading of specific staining in skin sections during microscopic examination, and allows better appreciation of morphological detail.

TL;DR: The technique was reproducible and could be applied to the analysis of nanograms of retinol and dehydroretinol in small (10-30 mg) skin specimens and the amounts of acidic retinoids were usually below the detection limit of the method (less than 10 ng/g) but the approach may be useful at the higher levels attained during retinoid therapy.