Showing papers by "Geraldine S. Pinkus published in 2022"
TL;DR: Interferon regulatory factor 8 (IRF8) is a member of the IRF family that is specific to the hematopoietic cell and is involved in regulating the development of human monocytic and dendritic-lineage cells, as well as B-cells as mentioned in this paper .
5 citations
TL;DR: Hypercellular bone marrow biopsy containing approximately 95% intermediate to large-sized neoplastic cells with irregular nuclei, mostly dispersed chromatin, small nucleoli, and small amounts of cytoplasm is presented.
Abstract: IMAGE 1 Upper panels: Intermediate to large-sized neoplastic cells present in the peripheral blood smear that were thought to be monocytic blasts on preliminary examination at an outside hospital (Wright Giemsa stain, original magnification 500). Middle panels: Flow cytometric analysis reveals the presence of intermediate to largesized neoplastic cells, based on forward light scatter (FSC), that are positive for CD45, T-cell markers CD3 and CD5, and negative for CD2 and CD7. Lower panels: Hypercellular bone marrow biopsy containing approximately 95% intermediate to large-sized neoplastic cells with irregular nuclei, mostly dispersed chromatin, small nucleoli, and small amounts of cytoplasm (left panel; Hematoxylin and Eosin, original magnification 400), that were positive for T-cell marker CD3 by immunohistochemical staining (right panel: original magnification 400) Received: 15 December 2021 Revised: 12 January 2022 Accepted: 13 January 2022
1 citations
TL;DR: Findings suggest cardiac megakaryocytes may be representative of a nonspecific inflammatory response and are frequent in, but not exclusive to, COVID‐19 autopsies.
Abstract: Thromboembolic phenomena are an important complication of infection by severe acute respiratory coronavirus 2 (SARS‐CoV‐2). Increasing focus on the management of the thrombotic complications of Coronavirus Disease 2019 (COVID‐19) has led to further investigation into the role of platelets, and their precursor cell, the megakaryocyte, during the disease course. Previously published postmortem evaluations of patients who succumbed to COVID‐19 have reported the presence of megakaryocytes in the cardiac microvasculature. Our series evaluated a cohort of autopsies performed on SARS‐CoV‐2‐positive patients in 2020 (n = 36) and prepandemic autopsies performed in early 2020 (n = 12) and selected to represent comorbidities common in cases of severe COVID‐19, in addition to infectious and noninfectious pulmonary disease and thromboembolic phenomena. Cases were assessed for the presence of cardiac megakaryocytes and correlated with the presence of pulmonary emboli and laboratory platelet parameters and inflammatory markers. Cardiac megakaryocytes were detected in 64% (23/36) of COVID‐19 autopsies, and 40% (5/12) prepandemic autopsies, with averages of 1.77 and 0.84 megakaryocytes per cm2, respectively. Within the COVID‐19 cohort, autopsies with detected megakaryocytes had significantly higher platelet counts compared with cases throughout; other platelet parameters were not statistically significant between groups. Although studies have supported a role of platelets and megakaryocytes in the response to viral infections, including SARS‐CoV‐2, our findings suggest cardiac megakaryocytes may be representative of a nonspecific inflammatory response and are frequent in, but not exclusive to, COVID‐19 autopsies.
TL;DR: In this article , complex karyotype (CK) is associated with adverse outcome in myeloid neoplasms (MN) with NPM1 mutation and NPM2 mutation.