R
Robert F. Padera
Researcher at Brigham and Women's Hospital
Publications - 226
Citations - 24584
Robert F. Padera is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Lung cancer & Cancer. The author has an hindex of 73, co-authored 207 publications receiving 20261 citations. Previous affiliations of Robert F. Padera include University of Nottingham & Harvard University.
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Journal ArticleDOI
BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models.
Daizong Li,Lauren Ambrogio,Lauren Ambrogio,Takeshi Shimamura,Shigeto Kubo,Masaya Takahashi,Lucian R. Chirieac,Robert F. Padera,Geoffrey I. Shapiro,Anke Baum,Frank Himmelsbach,Wolfgang J. Rettig,Matthew Meyerson,Matthew Meyerson,F. Solca,Heidi Greulich,Heidi Greulich,K-K Wong +17 more
TL;DR: It is shown that BIBW2992, an anilino-quinazoline designed to irreversibly bind EGFR and HER2, potently suppresses the kinase activity of wild-type and activated EGFRand HER2 mutants, including erlotinib-resistant isoforms.
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Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers
Jeffrey A. Engelman,Jeffrey A. Engelman,Liang Chen,Xiaohong Tan,Katherine Crosby,Alexander R. Guimaraes,Rabi Upadhyay,S. Michel Maira,Kate McNamara,Samanthi A. Perera,Youngchul Song,Lucian R. Chirieac,Ramneet Kaur,Angela Lightbown,Jessica Simendinger,Timothy Q. Li,Robert F. Padera,Carlos Garcia-Echeverria,Ralph Weissleder,Umar Mahmood,Lewis C. Cantley,Lewis C. Cantley,Kwok-Kin Wong +22 more
TL;DR: In vivo studies suggest that inhibitors of the PI3K-mTOR pathway may be active in cancers with PIK3CA mutations and, when combined with MEK inhibitors, may effectively treat KRAS mutated lung cancers.
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Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients
F. Stephen Hodi,Martin C. Mihm,Robert J. Soiffer,Frank G. Haluska,Marcus O. Butler,Michael V. Seiden,Thomas A. Davis,Rochele Henry-Spires,Suzanne MacRae,Ann Willman,Robert F. Padera,Michael T. Jaklitsch,Sridhar Shankar,Teresa C. Chen,Alan J. Korman,James P. Allison,Glenn Dranoff +16 more
TL;DR: Findings suggest that CTLA-4 antibody blockade increases tumor immunity in some previously vaccinated cancer patients.
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LKB1 modulates lung cancer differentiation and metastasis
Hongbin Ji,Matthew R. Ramsey,D. Neil Hayes,Cheng Fan,Kate McNamara,Piotr Kozlowski,Chad Torrice,Michael C. Wu,Takeshi Shimamura,Samanthi A. Perera,Mei-Chih Liang,Dongpo Cai,George N. Naumov,Lei Bao,Cristina Contreras,Danan Li,Liang Chen,Janakiraman Krishnamurthy,Jussi Koivunen,Lucian R. Chirieac,Robert F. Padera,Roderick T. Bronson,Neal I. Lindeman,David C. Christiani,Xihong Lin,Geoffrey I. Shapiro,Pasi A. Jänne,Bruce E. Johnson,Matthew Meyerson,David J. Kwiatkowski,Diego H. Castrillon,Nabeel Bardeesy,Norman E. Sharpless,Kwok-Kin Wong +33 more
TL;DR: LKB1 is established as a critical barrier to pulmonary tumorigenesis, controlling initiation, differentiation and metastasis in lung cancer, and expression profiling in human lung cancer cell lines and mouse lung tumours identified a variety of metastasis-promoting genes as targets of LKB1 repression.
Journal ArticleDOI
Persistence and Evolution of SARS-CoV-2 in an Immunocompromised Host.
Bina Choi,Manish Chandra Choudhary,James Regan,Jeffrey A. Sparks,Robert F. Padera,Xueting Qiu,Isaac H. Solomon,Hsiao Hsuan Kuo,Julie Boucau,Kathryn Bowman,U. Das Adhikari,Marisa L. Winkler,Alisa A. Mueller,Tiffany Y.T. Hsu,Michaël Desjardins,Lindsey R. Baden,Brian Chan,Bruce D. Walker,Mathias Lichterfeld,Manfred Brigl,Douglas S. Kwon,Sanjat Kanjilal,Eugene T Richardson,A. Helena Jonsson,Galit Alter,Amy K. Barczak,William P. Hanage,Xu G. Yu,Gaurav D. Gaiha,Michael S. Seaman,Manuela Cernadas,Jonathan Z. Li +31 more
TL;DR: An immunocompromised patient who had persistent infection with SARS-CoV-2 over a period of months, despite several courses of treatment, is described.