G
Gerard Schmid
Researcher at Hoffmann-La Roche
Publications - 39
Citations - 1280
Gerard Schmid is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Alkyl & Cephem. The author has an hindex of 13, co-authored 39 publications receiving 1224 citations. Previous affiliations of Gerard Schmid include La Roche College.
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“Scaffold-Hopping” by Topological Pharmacophore Search: A Contribution to Virtual Screening
TL;DR: A chemically advanced template search based on topological pharmacophore models has been developed as a technique for virtual screening and has successfully identified novel potent Ca(2+) antagonists in a library of several hundred thousand compounds on the basis of a correlation vector representation.
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Design and Synthesis of Potent and Highly Selective Thrombin Inhibitors.
Kurt Hilpert,J. Ackermann,David Banner,A. Gast,Klaus Gubernator,Paul Hadvary,L Labler,Klaus Müller,Gerard Schmid,T.B. Tschopp +9 more
TL;DR: From this series of thrombin inhibitors, 19f(Ro 46-6240) was selected for clinical development as an antithrombotic agent for intravenous administration and shows inhibitory activities in the picomolar range, low toxicity, and a short plasma half life which favors its use for an intravenous application.
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An enantioselective β-lactam synthesis starting from L-(S)-glyceraldehyde acetonide
TL;DR: Complete diastereoselectivity is observed during the cyclocondensation of activated glycine derivatives with aldimines derived from L-(S)-glyceraldehyde acetonide.
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Dimerization of extracellular domains of platelet-derived growth factor receptors. A revised model of receptor-ligand interaction.
TL;DR: A revised model of receptor-ligand interaction is led to and it is indicated that monomeric PDGF should be able to dimerize PDGF receptors.