[신간의 별자리x] 우리/미술, 그리고 ‘슬픔의 박물관’

From the Publisher: 
The accessible presentation of this book gives both a general view of the entire computer vision enterprise and also offers sufficient detail to be able to build useful applications. Users learn techniques that have proven to be useful by first-hand experience and a wide range of mathematical methods. A CD-ROM with every copy of the text contains source code for programming practice, color images, and illustrative movies. Comprehensive and up-to-date, this book includes essential topics that either reflect practical significance or are of theoretical importance. Topics are discussed in substantial and increasing depth. Application surveys describe numerous important application areas such as image based rendering and digital libraries. Many important algorithms broken down and illustrated in pseudo code. Appropriate for use by engineers as a comprehensive reference to the computer vision enterprise.

Computer vision : a modern approach = 计算机视觉 : 一种现代的方法

A paradigm shift is taking place in medicine from using synthetic implants and tissue grafts to a tissue engineering approach that uses degradable porous material scaffolds integrated with biological cells or molecules to regenerate tissues. This new paradigm requires scaffolds that balance temporary mechanical function with mass transport to aid biological delivery and tissue regeneration. Little is known quantitatively about this balance as early scaffolds were not fabricated with precise porous architecture. Recent advances in both computational topology design (CTD) and solid free-form fabrication (SFF) have made it possible to create scaffolds with controlled architecture. This paper reviews the integration of CTD with SFF to build designer tissue-engineering scaffolds. It also details the mechanical properties and tissue regeneration achieved using designer scaffolds. Finally, future directions are suggested for using designer scaffolds with in vivo experimentation to optimize tissue-engineering treatments, and coupling designer scaffolds with cell printing to create designer material/biofactor hybrids.

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Porous scaffold design for tissue engineering

In this paper we develop a new constitutive law for the description of the (passive) mechanical response of arterial tissue. The artery is modeled as a thick-walled nonlinearly elastic circular cylindrical tube consisting of two layers corresponding to the media and adventitia (the solid mechanically relevant layers in healthy tissue). Each layer is treated as a fiber-reinforced material with the fibers corresponding to the collagenous component of the material and symmetrically disposed with respect to the cylinder axis. The resulting constitutive law is orthotropic in each layer. Fiber orientations obtained from a statistical analysis of histological sections from each arterial layer are used. A specific form of the law, which requires only three material parameters for each layer, is used to study the response of an artery under combined axial extension, inflation and torsion. The characteristic and very important residual stress in an artery in vitro is accounted for by assuming that the natural (unstressed and unstrained) configuration of the material corresponds to an open sector of a tube, which is then closed by an initial bending to form a load-free, but stressed, circular cylindrical configuration prior to application of the extension, inflation and torsion. The effect of residual stress on the stress distribution through the deformed arterial wall in the physiological state is examined. The model is fitted to available data on arteries and its predictions are assessed for the considered combined loadings. It is explained how the new model is designed to avoid certain mechanical, mathematical and computational deficiencies evident in currently available phenomenological models. A critical review of these models is provided by way of background to the development of the new model.

https://hal.archives-ouvertes.fr/hal-01297725/document

A new constitutive framework for arterial wall mechanics and a comparative study of material models

Constitutive relations are fundamental to the solution of problems in continuum mechanics, and are required in the study of, for example, mechanically dominated clinical interventions involving soft biological tissues. Structural continuum constitutive models of arterial layers integrate information about the tissue morphology and therefore allow investigation of the interrelation between structure and function in response to mechanical loading. Collagen fibres are key ingredients in the structure of arteries. In the media (the middle layer of the artery wall) they are arranged in two helically distributed families with a small pitch and very little dispersion in their orientation (i.e. they are aligned quite close to the circumferential direction). By contrast, in the adventitial and intimal layers, the orientation of the collagen fibres is dispersed, as shown by polarized light microscopy of stained arterial tissue. As a result, continuum models that do not account for the dispersion are not able to capture accurately the stress–strain response of these layers. The purpose of this paper, therefore, is to develop a structural continuum framework that is able to represent the dispersion of the collagen fibre orientation. This then allows the development of a new hyperelastic free-energy function that is particularly suited for representing the anisotropic elastic properties of adventitial and intimal layers of arterial walls, and is a generalization of the fibre-reinforced structural model introduced by Holzapfel & Gasser (Holzapfel & Gasser 2001 Comput. Meth. Appl. Mech. Eng. 190, 4379–4403) and Holzapfel et al. (Holzapfel et al. 2000 J. Elast. 61, 1–48). The model incorporates an additional scalar structure parameter that characterizes the dispersed collagen orientation. An efficient finite element implementation of the model is then presented and numerical examples show that the dispersion of the orientation of collagen fibres in the adventitia of human iliac arteries has a significant effect on their mechanical response.

https://royalsocietypublishing.org/doi/pdf/10.1098/rsif.2005.0073

Hyperelastic modelling of arterial layers with distributed collagen fibre orientations

An automatic computer-based analysis of histological sections, which are differently stained, requires that they are related to each other. Histological images are, in general, accompanied with several artifacts and different contrasts, which require non-rigid registration. In this proceedings we present a novel hierarchical non-rigid registration algorithm able to align images, which contain small image artifacts. The proposed algorithm is decomposed into a fast coarse rigid registration step and a slower, but finer non-rigid step using the elastic thin-plate spline interpolation. Accuracy tests, performed for histological images obtained from human arteries, have shown that the error measure is acceptable, and that the image noise does not cause any problem. The algorithm can be applied to various multi-contrast elastic registration problems in medical imaging.

Non-rigid registration for stained histological sections of atherosclerotic arteries

Abstract Collagen plays a key role in the strength of aortic walls, so studying micro-structural changes during disease development is critical to better understand collagen reorganization. Second-harmonic generation microscopy is used to obtain images of human aortic collagen in both healthy and diseased states. Methods are being developed in order to efficiently determine the waviness, that is, tortuosity and amplitude, as well as the diameter, orientation, and dispersion of collagen fibers, and bundles in healthy and aneurysmal tissues. The results show layer-specific differences in the collagen of healthy tissues, which decrease in samples of aneurysmal aortic walls. In healthy tissues, the thick collagen bundles of the adventitia are characterized by greater waviness, both in the tortuosity and in the amplitude, compared to the relatively thin and straighter collagen fibers of the media. In contrast, most aneurysmal tissues tend to have a more uniform structure of the aortic wall with no significant difference in collagen diameter between the luminal and abluminal layers. An increase in collagen tortuosity compared to the healthy media is also observed in the aneurysmal luminal layer. The data set provided can help improve related material and multiscale models of aortic walls and aneurysm formation.

https://www.cambridge.org/core/services/aop-cambridge-core/content/view/AC8215F45DA65C8870CDC24E42C5E778/S1431927622000629a.pdf/div-class-title-differences-in-collagen-fiber-diameter-and-waviness-between-healthy-and-aneurysmal-abdominal-aortas-div.pdf

Differences in Collagen Fiber Diameter and Waviness between Healthy and Aneurysmal Abdominal Aortas

Three-Dimensional Modeling and Computational Analysis of the Human Cornea Considering Distributed Collagen Fibril

Numerical analyses of the interrelation between extracellular smooth muscle orientation and intracellular filament overlap in the human abdominal aorta

Arterial lumen reductions result in hypertension and possibly rupture of plaque deposits as a consequence of atherosclerotic degeneration which can finally cause a heart attack or a stroke. Hence, therapeutical treatments such as balloon angioplasty and stenting are required. The aim of this work is to propose a new model for the softening hysteresis observed in overstretched arterial tissues and related computer simulations. The physiological loading domain is described by a purely elastic polyconvex anisotropic strain-energy function, which is decoupled into an isotropic part related to the non-collagenous matrix material, and into a transversely isotropic part related to the embedded (collagen) fibers. A scalar-valued damage variable is taken into account for the fibers to cover a saturation function converging to a maximal damage value at a fixed maximum load level. In addition, the model captures remnant strains in the fiber direction after unloading. (© 2009 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim)

https://onlinelibrary.wiley.com/doi/pdf/10.1002/pamm.200910052

Gerhard Holzapfel

Papers

Non-rigid registration for stained histological sections of atherosclerotic arteries

Differences in Collagen Fiber Diameter and Waviness between Healthy and Aneurysmal Abdominal Aortas

Three-Dimensional Modeling and Computational Analysis of the Human Cornea Considering Distributed Collagen Fibril

Numerical analyses of the interrelation between extracellular smooth muscle orientation and intracellular filament overlap in the human abdominal aorta

Simulation of Damage Hysteresis in Soft Biological Tissues