G
Gerrit J. Poelarends
Researcher at University of Groningen
Publications - 154
Citations - 4385
Gerrit J. Poelarends is an academic researcher from University of Groningen. The author has contributed to research in topics: 4-Oxalocrotonate tautomerase & Dehalogenase. The author has an hindex of 36, co-authored 143 publications receiving 3807 citations. Previous affiliations of Gerrit J. Poelarends include University of Texas at Austin.
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Journal ArticleDOI
Functional and structural characterization of an unusual cofactor-independent oxygenase.
Bert-Jan Baas,Harshwardhan Poddar,Edzard M. Geertsema,Henriëtte J. Rozeboom,Marcel P. de Vries,Hjalmar P. Permentier,Andy-Mark W. H. Thunnissen,Gerrit J. Poelarends +7 more
TL;DR: It is shown that an enzyme of unknown activity, RhCC from Rhodococcus jostii RHA1, functions as an oxygenase, using 4-hydroxyphenylenolpyruvate as a substrate, and the structure shows the absence of cofactors, establishing RhCC as a rare example of a redox-metal- and coenzyme-free oxygenase.
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Chemoenzymatic Synthesis of ortho-, meta-, and para-Substituted Derivatives of L-threo-3-Benzyloxyaspartate, An Important Glutamate Transporter Blocker
Jandre de Villiers,Marianne de Villiers,Edzard M. Geertsema,Hans Raj,Hans Raj,Gerrit J. Poelarends +5 more
TL;DR: A new chemical procedure for the synthesis of racemic mixtures of TBOA and its derivatives was explored, which are valuable reference compounds in chiral‐phase HPLC to establish the enantiopurities of the corresponding chemoenzymatically prepared amino acids.
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Multidrug Transporters in Lactic Acid Bacteria
TL;DR: The existing data on Multi-Drug Resistance systems are summarized and recent observations are discussed that suggest the use of new strategies in the ongoing battle against drug-resistant microbial pathogens.
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Unlocking Asymmetric Michael Additions in an Archetypical Class I Aldolase by Directed Evolution
Andreas Kunzendorf,Guangcai Xu,Jesse J H van der Velde,Henriëtte J. Rozeboom,Andy-Mark W. H. Thunnissen,Gerrit J. Poelarends +5 more
TL;DR: In this article, the 2-deoxy-d-ribose-5-phosphate aldolase (DERA) was designed to catalyze enantioselective Michael addition of nitromethane to α,β-unsaturated aldehydes to yield various pharmaceutically relevant chiral synthons.
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Biocatalytic Enantioselective Hydroaminations for Production of N-Cycloalkyl-Substituted L-Aspartic Acids Using Two C-N Lyases
TL;DR: Given its very broad amine scope, EDDS lyase is an exceptionally powerful synthetic tool that nicely complements the rapidly expanding toolbox of biocatalysts for asymmetric synthesis of noncanonical amino acids.