G
Gesuino Angius
Researcher at Sapienza University of Rome
Publications - 3
Citations - 46
Gesuino Angius is an academic researcher from Sapienza University of Rome. The author has contributed to research in topics: Cancer & DNA repair. The author has an hindex of 2, co-authored 3 publications receiving 29 citations.
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Prexasertib, a checkpoint kinase inhibitor: from preclinical data to clinical development
TL;DR: The preclinical data and early clinical studies advocate the use of prexasertib in solid tumors both in monotherapy and in combination with other drugs (antimetabolites, PARP inhibitors and platinum-based chemotherapy); the safety and the efficacy of combination therapies with prex asertib need to be better evaluated in ongoing clinical trials.
Journal ArticleDOI
Family history of cancer as surrogate predictor for immunotherapy with anti-PD1/PD-L1 agents: preliminary report of the FAMI-L1 study.
Alessio Cortellini,Melissa Bersanelli,Sebastiano Buti,Elisabetta Gambale,Francesco Atzori,Federica Zoratto,Alessandro Parisi,Davide Brocco,Annagrazia Pireddu,Katia Cannita,Daniela Iacono,Maria Rita Migliorino,Teresa Gamucci,Michele De Tursi,Tina Sidoni,Marcello Tiseo,Maria Michiara,Anselmo Papa,Gesuino Angius,Silverio Tomao,Maria Concetta Fargnoli,Clara Natoli,Corrado Ficorella +22 more
TL;DR: This pilot study seems to individuate easily available patient's features as possible predictive surrogates of clinical benefit for anti-PD-1/PD-L1 treatments, and need to be confirmed with a greater sample size, in prospective trials with immunotherapy.
Journal ArticleDOI
[Innovations in the treatment of ovarian cancer. Analysis of the therapeutic development: from platinum to immunotherapy.]
TL;DR: After 20 years of chemotherapy alone, new targeted therapies are emerging that will help changing the therapeutic approach, making treatments increasingly personalized.