D
Davide Brocco
Researcher at University of Chieti-Pescara
Publications - 31
Citations - 528
Davide Brocco is an academic researcher from University of Chieti-Pescara. The author has contributed to research in topics: Medicine & Cancer. The author has an hindex of 9, co-authored 20 publications receiving 282 citations.
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Journal ArticleDOI
Clinical Outcomes of Patients with Advanced Cancer and Pre-Existing Autoimmune Diseases Treated with Anti-Programmed Death-1 Immunotherapy: A Real-World Transverse Study
Alessio Cortellini,Sebastiano Buti,Daniele Santini,Fabiana Perrone,Raffaele Giusti,Marcello Tiseo,Melissa Bersanelli,Maria Michiara,Antonino Grassadonia,Davide Brocco,Nicola Tinari,Michele De Tursi,Federica Zoratto,Enzo Veltri,Riccardo Marconcini,Francesco Malorgio,Carlo Garufi,Marco Russano,Cecilia Anesi,Tea Zeppola,Marco Filetti,Paolo Marchetti,Andrea Botticelli,Gian Carlo Antonini Cappellini,Federica De Galitiis,Maria Giuseppa Vitale,Roberto Sabbatini,Sergio Bracarda,Rossana Berardi,Silvia Rinaldi,Marianna Tudini,Rosa Rita Silva,Annagrazia Pireddu,Francesco Atzori,Rita Chiari,Biagio Ricciuti,Daniela Iacono,Maria Rita Migliorino,Antonio Rossi,Giampiero Porzio,Katia Cannita,Valeria Ciciarelli,Maria Concetta Fargnoli,Paolo A. Ascierto,Corrado Ficorella +44 more
TL;DR: The finding of a greater incidence of irAEs among female patients ranks among the "hot topics" in gender-related differences in immuno-oncology.
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Effect of Gender on the Outcome of Patients Receiving Immune Checkpoint Inhibitors for Advanced Cancer: A Systematic Review and Meta-Analysis of Phase III Randomized Clinical Trials
Antonino Grassadonia,Isabella Sperduti,Patrizia Vici,Laura Iezzi,Davide Brocco,Teresa Gamucci,Laura Pizzuti,Marcello Maugeri-Saccà,Paolo Marchetti,Gaetana Cognetti,Michele De Tursi,Clara Natoli,Maddalena Barba,Nicola Tinari +13 more
TL;DR: Conclusively, ICIs use was associated with more favorable outcomes in men, particularly for anti-CTLA-4 agents, in melanoma, not gender-related factors may influence the anti-tumor immune response evoked by ICIs.
Journal ArticleDOI
Weighing the role of skeletal muscle mass and muscle density in cancer patients receiving PD-1/PD-L1 checkpoint inhibitors: a multicenter real-life study
Alessio Cortellini,Federico Bozzetti,Pierpaolo Palumbo,Davide Brocco,Pietro Di Marino,Nicola Tinari,Michele De Tursi,Veronica Agostinelli,Leonardo Patruno,Cristina Valdesi,Manuela Mereu,Lucilla Verna,Paola Lanfiuti Baldi,Olga Venditti,Katia Cannita,Carlo Masciocchi,Antonio Barile,Jennifer L. McQuade,Corrado Ficorella,Giampiero Porzio +19 more
TL;DR: Low SMI is associated with shortened survival in advanced cancer patients treated with PD1/PDL1 checkpoint inhibitors and the lack of an association between SMI and clinical response suggests that sarcopenia may be generally prognostic in this setting rather than specifically predictive of response to immunotherapy.
Journal ArticleDOI
Predictive value of skeletal muscle mass for immunotherapy with nivolumab in non‐small cell lung cancer patients: A “hypothesis‐generator” preliminary report
Alessio Cortellini,Lucilla Verna,Giampiero Porzio,Federico Bozzetti,Pierpaolo Palumbo,Carlo Masciocchi,Katia Cannita,Alessandro Parisi,Davide Brocco,Nicola Tinari,Corrado Ficorella +10 more
TL;DR: In their opinion, nutritional status could affect the clinical outcomes of immunotherapy, even if the authors cannot make definitive conclusions here, and further studies on the topic are required.
Journal ArticleDOI
Circulating Cancer Stem Cell-Derived Extracellular Vesicles as a Novel Biomarker for Clinical Outcome Evaluation.
Davide Brocco,Paola Lanuti,Paola Simeone,Giuseppina Bologna,Damiana Pieragostino,Maria Concetta Cufaro,Vincenzo Graziano,Vincenzo Graziano,Marta Peri,P. Di Marino,M. De Tursi,Antonino Grassadonia,I. G. Rapposelli,Laura Pierdomenico,Eva Ercolino,Fausta Ciccocioppo,P. Del Boccio,Marco Marchisio,Clara Natoli,Sebastiano Miscia,Nicola Tinari +20 more
TL;DR: Flow cytometry data strongly suggest that blood circulating cancer stem cell-derived EVs may have a role as a diagnostic and prognostic biomarker in cancer.