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Gianluca De Rienzo
Researcher at Massachusetts Institute of Technology
Publications - 8
Citations - 421
Gianluca De Rienzo is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Wnt signaling pathway & Zebrafish. The author has an hindex of 6, co-authored 7 publications receiving 380 citations. Previous affiliations of Gianluca De Rienzo include Broad Institute.
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Journal ArticleDOI
Common DISC1 Polymorphisms Disrupt Wnt/GSK3β Signaling and Brain Development
Karun K. Singh,Gianluca De Rienzo,Gianluca De Rienzo,Laurel Drane,Yingwei Mao,Zachary Flood,Jon M. Madison,Manuel A. R. Ferreira,Manuel A. R. Ferreira,Sarah E. Bergen,Sarah E. Bergen,Cillian King,Pamela Sklar,Pamela Sklar,Hazel Sive,Hazel Sive,Li-Huei Tsai +16 more
TL;DR: It is demonstrated using mouse, zebrafish, and human model systems that DISC1 variants are loss of function in Wnt/GSK3β signaling and disrupt brain development and elucidate a possible mechanism for their role in neuropsychiatric phenotypes.
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Zebrafish homologs of genes within 16p11.2, a genomic region associated with brain disorders, are active during brain development, and include two deletion dosage sensor genes
TL;DR: The first major finding is that the 16p11.2 region comprises a highly active set of genes, which could present a large genetic target and might explain why multiple brain function, and other, phenotypes are associated with this interval.
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Efficient shRNA-Mediated Inhibition of Gene Expression in Zebrafish
TL;DR: It is demonstrated that for two genes, wnt5b and zDisc1, each with described mutant and morphant phenotypes, shRNAs efficiently decrease endogenous RNA levels, and conditional LOF can be readily obtained.
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Brain activity patterns in high-throughput electrophysiology screen predict both drug efficacies and side effects.
Peter M. Eimon,Mostafa Ghannad-Rezaie,Gianluca De Rienzo,Amin Allalou,Yuelong Wu,Mu Gao,Ambrish Roy,Jeffrey Skolnick,Mehmet Fatih Yanik +8 more
TL;DR: A multi-channel recording platform based on a zebrafish genetic model of epilepsy to screen for antiepileptic drugs and the highest-ranked compounds identified by BAP analysis exhibit far greater anti-seizure efficacy and fewer side effects during subsequent in-depth behavioral assessment.
Journal ArticleDOI
Disc1 regulates both β-catenin-mediated and noncanonical Wnt signaling during vertebrate embryogenesis
Gianluca De Rienzo,Joshua A. Bishop,Joshua A. Bishop,Yingwei Mao,Luyuan Pan,Taylur P. Ma,Cecilia B. Moens,Li-Huei Tsai,Li-Huei Tsai,Hazel Sive +9 more
TL;DR: This is the first demonstration that Disc1 modulates the noncanonical Wnt pathway and suggests a previously unconsidered mechanism by which Disc1 may contribute to the etiology of neuropsychiatric disorders.