Anti-inflammatory effects of compounds alpha-humulene and (−)-trans-caryophyllene isolated from the essential oil of Cordia verbenacea

Medicinal plants in Brazil: Pharmacological studies, drug discovery, challenges and perspectives.

Anti-inflammatory and anti-allergic properties of the essential oil and active compounds from Cordia verbenacea

The biosynthesis and biotechnological production of Rosmarinic acid, a phenolic ester that is widespread in the plant kingdom, has been widely investigated. This compound has shown many remarkable biological and pharmacological activities, which have led to its pharmaceutical and analytical development, as well as clinical studies, which are summarized and analyzed here for the first time. This review compiles data from the Pubmed, Scopus, Scifinder, Web Of Science, and Science Direct databases published between 1990 and 2015, restricting the search to works with the keywords “Rosmarinic acid” in the title. The initial search identified more than 800 articles; after an initial screening and removal of duplicate works, the search was further refined, resulting in approximately 300 articles that were scrutinized and comprise this review. The articles were organized to describe extraction and isolation, analytical methods, pharmaceutical development, and biological and pharmacological activities [divided into nonclinical (in vitro, in vivo) and clinical studies], pharmacokinetic studies, and stability studies.

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Rosmarinic Acid--Pharmaceutical and Clinical Aspects.

Snake bite, a major socio-medical problem of south east asian countries is still depending on the usage of antisera as the one and only source of treatment, which has its own limitations. In India, mostly in rural areas, health centres are inadequate and the snake bite victims mostly depend on traditional healers and herbal antidotes, as an alternative treatment. The present review has been focussed on the varied folk and traditional herbs and their antisnake venom compounds, which might be a stepping stone in establishing the future therapy against snake bite treatment and management.

Herbs and herbal constituents active against snake bite.

Rosmarinic acid, a new snake venom phospholipase A2 inhibitor from Cordia verbenacea (Boraginaceae): antiserum action potentiation and molecular interaction

Crystal structure of myotoxin-II: A myotoxic phospholipase A2 - Homologue from Bothrops moojeni venom.

Crystallization and preliminary X-ray diffraction studies of BnSP-6, a myotoxic phospholipase A2 from Bothrops neuwiedi venom

Acid–base balance in the hæmolymph of European abalone (Haliotis 1 tuberculata) exposed to CO2-induced ocean acidification 2 Stéphanie Auzoux-Bordenave1, Sandra Chevret1, Aicha Badou2, Sophie Martin3, Sarah Di 3 Giglio4, Philippe Dubois4 4 1Laboratoire de Biologie des Organismes et Ecosystèmes Aquatiques (BOREA), Muséum national 5 d'Histoire naturelle/CNRS/IRD/Sorbonne Université/UCN/UA, Station marine de Concarneau, 29900 6 Concarneau, France. 7 2Direction Générale Déléguée à la Recherche, l’Expertise, la Valorisation et l’Enseignement (DGD 8 REVE), Muséum national d'Histoire naturelle, Station marine de Concarneau, 29900 Concarneau, 9 France 10 3UMR 7144 "Adaptation et Diversité en Milieu Marin" (AD2M), CNRS/SU, Station Biologique de 11 Roscoff, 29680 Roscoff Cedex, France 12 4Laboratoire de Biologie Marine, Université Libre de Bruxelles, CP160/15, 1050, Brussels, Belgium 13 14 Corresponding author: Stéphanie Auzoux-Bordenave, Tel: +33 2 98 50 42 88, 15 E-mail: stephanie.auzoux-bordenave@mnhn.fr 16 17 18 Abstract 19

Giglio

Papers

Rosmarinic acid, a new snake venom phospholipase A2 inhibitor from Cordia verbenacea (Boraginaceae): antiserum action potentiation and molecular interaction

Crystal structure of myotoxin-II: A myotoxic phospholipase A2 - Homologue from Bothrops moojeni venom.

Crystallization and preliminary X-ray diffraction studies of BnSP-6, a myotoxic phospholipase A2 from Bothrops neuwiedi venom

Acid–base balance in the hæmolymph of European abalone (Haliotis