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Gigliola Sica

Researcher at Catholic University of the Sacred Heart

Publications -  125
Citations -  2857

Gigliola Sica is an academic researcher from Catholic University of the Sacred Heart. The author has contributed to research in topics: Receptor & Cancer cell. The author has an hindex of 25, co-authored 124 publications receiving 2508 citations. Previous affiliations of Gigliola Sica include Agostino Gemelli University Polyclinic & The Catholic University of America.

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Local overexpression of V1a-vasopressin receptor enhances regeneration in tumor necrosis factor-induced muscle atrophy.

TL;DR: A novel in vivo role for AVP-dependent pathways is highlighted, which may represent an interesting strategy to counteract muscle decline in aging or in muscular pathologies.
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B cell depletion in diffuse progressive systemic sclerosis: safety, skin score modification and IL-6 modulation in an up to thirty-six months follow-up open-label trial

TL;DR: Anti-CD20 treatment has been well tolerated and SSc patients experienced an improvement of the skin score and of clinical symptoms and the clear fall in IL-6 levels could contribute to the skin fibrosis improvement, while the presence of B cells in the skin seems to be irrelevant with respect to the outcome.
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Pathological and Molecular Features of Glioblastoma and Its Peritumoral Tissue

TL;DR: The aim of this review is to recapitulate the pathological features of GBM and of the peritumoral region associated with progression and recurrence and to suggest new immunotherapeutic strategies.
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Epithelial-Stromal Interactions in Human Breast Cancer: Effects on Adhesion, Plasma Membrane Fluidity and Migration Speed and Directness

TL;DR: In this paper, the authors investigated whether the crosstalk between malignant cells and the stromal microenvironment heavily influence tumor progression by co-culturing mammary cancer cells exhibiting different degrees of metastatic potential (MDA-MB-231>MCF-7).
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Goserelin as ovarian protection in the adjuvant treatment of premenopausal breast cancer: a phase II pilot study.

TL;DR: The data show that the addition of goserelin to adjuvant therapy of premenopausal patients with early breast cancer is well tolerated and protects long-term ovarian function.