M
Maria De Santis
Researcher at Humanitas University
Publications - 83
Citations - 3669
Maria De Santis is an academic researcher from Humanitas University. The author has contributed to research in topics: Population & Rheumatoid arthritis. The author has an hindex of 29, co-authored 83 publications receiving 2601 citations. Previous affiliations of Maria De Santis include University of Milan & Catholic University of the Sacred Heart.
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Journal ArticleDOI
Mapping and predicting mortality from systemic sclerosis
Muriel Elhai,Christophe Meune,Marouane Boubaya,Jérôme Avouac,Eric Hachulla,Alexandra Balbir-Gurman,Gabriela Riemekasten,Paolo Airò,Beatriz Joven,Serena Vettori,Franco Cozzi,Susanne Ullman,László Czirják,Mohammed Tikly,Ulf Müller-Ladner,Paola Caramaschi,Oliver Distler,Florenzo Iannone,L. Ananieva,Roger Hesselstrand,R. Becvar,Armando Gabrielli,Nemanja Damjanov,Maria João Salvador,Valeria Riccieri,Carina Mihai,Gabriella Szücs,Ulrich A Walker,Nicolas Hunzelmann,Duska Martinovic,Vanessa Smith,Carolina de Souza Müller,Carlomaurizio Montecucco,Daniela Opris,Francesca Ingegnoli,Panayiotis G. Vlachoyiannopoulos,Bojana Stamenkovic,Edoardo Rosato,Stefan Heitmann,Jörg H W Distler,Thierry Zenone,Matthias Seidel,Alessandra Vacca,Ellen De Langhe,Srdan Novak,Maurizio Cutolo,Luc Mouthon,Jörg Henes,Carlo Chizzolini,Carlos Alberto Von Mühlen,Kamal Solanki,Simona Rednic,Lisa K. Stamp,Branimir Anić,Branimir Anić,Vera Ortiz Santamaria,Maria De Santis,Sule Yavuz,Walter Alberto Sifuentes-Giraldo,Emmanuel Chatelus,Jiri Stork,Jacob M van Laar,Esthela Loyo,Paloma García de la Peña Lefebvre,Kilian Eyerich,Vanesa Cosentino,Juan José Alegre-Sancho,Otylia Kowal-Bielecka,Grégoire Rey,Marco Matucci-Cerinic,Yannick Allanore +70 more
TL;DR: Combining two complementary and detailed databases enabled the collection of an unprecedented 3700 deaths, revealing the major contribution of the cardiopulmonary system to SSc mortality.
Journal ArticleDOI
Type III interferons disrupt the lung epithelial barrier upon viral recognition.
Achille Broggi,Sreya Ghosh,Benedetta Sposito,Benedetta Sposito,Roberto Spreafico,Fabio Balzarini,Fabio Balzarini,Antonino Lo Cascio,Antonino Lo Cascio,Nicola Clementi,Maria De Santis,Nicasio Mancini,Francesca Granucci,Ivan Zanoni,Ivan Zanoni +14 more
TL;DR: A strong rationale is provided for rethinking the pathophysiological role of IFN-λ and its possible use in clinical practice against endemic viruses, such as influenza virus as well as the emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
Journal ArticleDOI
Autoinflammatory and autoimmune conditions at the crossroad of COVID-19.
Yhojan Rodríguez,L. Novelli,Manuel Rojas,Maria De Santis,Yeny Acosta-Ampudia,Diana M. Monsalve,Carolina Ramírez-Santana,Antonio Costanzo,William M. Ridgway,Aftab A. Ansari,M. Eric Gershwin,Carlo Selmi,Juan-Manuel Anaya +12 more
TL;DR: A scoping review of the relevant immunological findings in COVID-19 as well as the current reports about autoimmune/autoinflammatory conditions associated with the disease are presented.
Journal ArticleDOI
Sarilumab in patients admitted to hospital with severe or critical COVID-19: a randomised, double-blind, placebo-controlled, phase 3 trial.
François-Xavier Lescure,Hitoshi Honda,Robert A. Fowler,Jennifer Sloane Lazar,Genming Shi,Peter Wung,Naimish Patel,Owen Hagino,Ignacio J. Bazzalo,Marcelo M. Casas,Sebastián A. Nuñez,Yael Pere,Carlos M. Ibarrola,Marco A. Solis Aramayo,Maria C. Cuesta,Andrea E. Duarte,Pablo M. Gutierrez Fernandez,Maria A. Iannantuono,Erica A. Miyazaki,Javier P. Silvio,Dario G. Scublinsky,Alessandra Bales,Daniela Catarino,Elie Fiss,Sara Mohrbacher,Victor Sato,Antonio Baylao,Adilson Joaquim Westheimer Cavalcante,Francini Correa,Celso A. de Andrade,Juvencio José Duailibe Furtado,Nelson Ribeiro Filho,Valeria Telles,Leopoldo T. Trevelin,Ricardo Vipich,Rodrigo Boldo,Paula Borges,Suzana Margareth Lobo,Graziela Luckemeyer,Luana Machado,Maysa B. Alves,Ana Caroline Iglessias,Marianna M. Lago,Daniel Wagner de Castro Lima Santos,Hugo Chapdelaine,Emilia L. Falcone,Rahima Jamal,Me-Linh Luong,Madeleine Durand,Stephane Doucet,Francois-martin Carrier,Bryan Coburn,Lorenzo Del Sorbo,Sharon Walmsley,Sara Belga,Luke Y.C. Chen,Allison D. Mah,Theodore Steiner,Alissa J. Wright,J. Hajek,Neill K. J. Adhikari,Nick Daneman,Kosar Khwaja,Jason Shahin,Carolina Gonzalez,Rafael Silva,Marcelo Lindh,Gabriel Maluenda,Patricia Fernandez,Maite Oyonarte,Martin Lasso,Alexandre Boyer,Didier Bronnimann,Hoang-Nam Bui,Charles Cazanave,Helene Chaussade,Arnaud Desclaux,Mailys Ducours,Alexandre Duvignaud,Denis Malvy,Lisa J. Martin,Didier Neau,Duc Nguyen,Thierry Pistone,Gaetane Soubrane-Wirth,Julie Leitao,Clotilde Allavena,Charlotte Biron,Sabelline Bouchez,Benjamin Gaborit,Antoine Gregoire,Paul Le Turnier,Anne-Sophie Lecompte,Raphael Lecomte,Maeva Lefebvre,Francois Raffi,David Boutoille,Pascale H. Morineau,Romain Guéry,Emmanuel Chatelus,Nathalie Dumoussaud,Renaud Felten,Florina Luca,Bernard Goichot,Francis Schneider,Marie-Caroline Taquet,Matthieu Groh,Mathilde Roumier,Mathilde Neuville,Antoine Bachelard,Valentina Isernia,F-Xavier Lescure,Bao-Chau Phung,Anne Rachline,Aurelie Sautereau,Dorothee Vallois,Yves Bleher,Delphine Boucher,Clémentine Coudon,Jean Esnault,Thomas Guimard,Sophie Leautez-Nainville,Dominique Merrien,Marine Morrier,Pauline Motte-Vincent,Romain Gabeff,Hélène Leclerc,Céline Cozic,Romain Decours,Ronan Février,Gwenhael Colin,Sophie Abgrall,Dorothee Vignes,Raluca Sterpu,Mira Kuellmar,Melanie Meersch-Dini,Raphael Weiss,Alexander Zarbock,Christiane Antony,Marc M. Berger,Thorsten Brenner,Christian Taube,Frank Herbstreit,Sebastian Dolff,Margarethe Konik,Karsten Schmidt,Markus Zettler,Oliver Witzke,Boris Boell,Jorge Garcia Borrega,Philipp Koehler,Thomas Zander,Fabian Dusse,Othman Al-Sawaf,Philipp Köhler,Dennis A. Eichenauer,Matthias Kochanek,Alexander Shimabukuro-Vornhagen,Sibylle C. Mellinghoff,Annika Claßen,Jan-Michel Heger,Charlotte Meyer-Schwickerath,Paul Liedgens,Katrin Heindel,Ana Belkin,Asaf Biber,Mayan Gilboa,Itzchak Levy,Vladislav Litachevsky,Galia Rahav,Anat Finesod Wiedner,Tal Zilberman-Daniels,Yonatan Oster,Jacob Strahilevitz,Sigal Sviri,Elena Baldissera,Corrado Campochiaro,Giulio Cavalli,Lorenzo Dagna,Giacomo De Luca,Emanuel Della Torre,Alessandro Tomelleri,Davide Bernasconi De Luca,Amedeo F. Capetti,Massimo Coen,Maria V. Cossu,Massimo Galli,Andrea Giacomelli,Guido A. Gubertini,Stefano Rusconi,Giulia Burastero,Margherita Digaetano,Giovanni Guaraldi,Marianna Meschiari,Cristina Mussini,Cinzia Puzzolante,Sara Volpi,Marina Aiello,Alarico Ariani,Alfredo Chetta,Annalisa Frizzelli,Andrea Ticinesi,Domenico Tuttolomondo,Stefano Aliberti,Francesco Blasi,Marta F. Di Pasquale,Sofia Misuraca,Tommaso Pilocane,Edoardo Simonetta,Alessio M. Aghelmo,Claudio Angelini,Enrico Brunetta,Giorgio Walter Canonica,Michele Ciccarelli,Sara Dal Farra,Maria De Santis,Sebastian Ferri,Marco Folci,Giacomo Maria Guidelli,Enrico Heffler,Ferdinando Loiacono,Giacomo Malipiero,Giovanni Paoletti,Rosa Pedale,Francesca A. Puggioni,Francesca Racca,Aurora Zumbo,Morihiko Satou,Tatyana Lisun,Denis Protsenko,Nikolay Rubtsov,Irina Beloglazova,Daria Fomina,Mariana Lysenko,Sofia Serdotetskova,Vitali Firstov,Ivan Gordeev,Ilia Kokorin,Ksenia Komissarova,Nina Lapochkina,Elena Luchinkina,Valentin Malimon,Sevinch Mamedguseyinova,Ksenia Polubatonova,Natalia Suvorova,Jose R. Arribas,Alberto M. Borobia Perez,Fernando de la Calle Prieto,Juan Carlos Figueira,Rocio Motejano Sanchez,Marta Mora-Rillo,Concepcion Prados Sanchez,Javier Queiruga Parada,Francisco Fernandez Arnalich,Maria Guerro Barrientos,Alejandro Bendala Estrada,Aranzazu Caballero Marcos,Maria E. Garcia Leoni,Rita García-Martínez,Ana María Collado,Patricia Munoz Garcia,Ana Torres do Rego,Maria Garcia,Almudena Burrillo,Maricela Valerio Minero,Paloma Gijon Vidaurreta,Sonsoles Infante Herrero,Elena Velilla,Marina Machado,María Olmedo,Blanca Pinilla,Benito Almirante Gragera,Maria de la Esperanza Cañas Ruano,Sofia Contreras Medina,Alejandro Cortés Herrera,Vicenç Falcó Ferrer,Ricard Ferrer Roca,Xavier Nuvials Casals,Esteve Ribera Pascuet,Paula Suanzes Diez,Pedro Rebollo Castro,Felipe Garcia Alcaide,Alejandro Soriano,Aina Oliver Caldes,Ana González Cordón,Celia Cardozo,Lorena De la Mora Cañizo,Romina Pena López,Sandra Chamorro,Clara Crespillo-Andujar,Rosa Escudero Sanchez,Jesús Fortún-Abete,Begoña Monge-Maillo,Ana Moreno Zamora,Francesca Norman,Matilde Sanchez Conde,Sergio Serrano Villar,Pilar Vizcarra +297 more
TL;DR: In this article, the authors evaluated the safety and efficacy of sarilumab, an interleukin-6 receptor inhibitor, in patients with severe (requiring supplemental oxygen by nasal cannula or face mask) or critical(requiring greater supplemental oxygen, mechanical ventilation, or extracorporeal support) COVID-19.
Journal ArticleDOI
B cell depletion in diffuse progressive systemic sclerosis: safety, skin score modification and IL-6 modulation in an up to thirty-six months follow-up open-label trial
Silvia Laura Bosello,Maria De Santis,Gina Lama,Cristina Spano,Cristiana Angelucci,Barbara Tolusso,Gigliola Sica,Gianfranco Ferraccioli +7 more
TL;DR: Anti-CD20 treatment has been well tolerated and SSc patients experienced an improvement of the skin score and of clinical symptoms and the clear fall in IL-6 levels could contribute to the skin fibrosis improvement, while the presence of B cells in the skin seems to be irrelevant with respect to the outcome.