Gildon Choi

TL;DR: The results indicate that IP(3)3-kinase(A) may play an important role in the regulation of LTP in hippocampal CA1 region through the generation of IP4, but the enhanced LTB in the hippocampalCA1 does not affect spatial learning and memory.

TL;DR: Mutational analysis of the two residues and other biochemical data strongly suggest that the hydrogen bond of Tyr14 provides the more significant contribution than that of Asp99 to the requisite 11 kcal/mol of energy for the catalytic power of KSI.

TL;DR: Proton nuclear magnetic resonance analyses of several mutant enzymes indicate that the Tyr14 OH forms a low barrier hydrogen bond with the dienolic oxyanion of the intermediate, indicating that the doubly hydrogen-bonded system over the dyad system.

TL;DR: A specific inhibitor for IP3K will be a useful tool to study the role of this enzyme in transmembrane signal.

TL;DR: In this article, mutations introduced into N-glycosylation sites (N220 of murine p40 and N222 of human p40) reduced secretion of p40 but not p70.