H
Hyun Soo Cho
Researcher at Yonsei University
Publications - 117
Citations - 6617
Hyun Soo Cho is an academic researcher from Yonsei University. The author has contributed to research in topics: Phosphorylation & Active site. The author has an hindex of 30, co-authored 113 publications receiving 6001 citations. Previous affiliations of Hyun Soo Cho include University of Tsukuba & Pohang University of Science and Technology.
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Journal ArticleDOI
Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab
Hyun Soo Cho,Karen Mason,Kasra X. Ramyar,Ann Marie Stanley,Sandra B. Gabelli,Dan W. Denney,Daniel J. Leahy +6 more
TL;DR: Crystal structures of the entire extracellular regions of rat and human HER2 reveal a fixed conformation for HER2 that resembles a ligand-activated state, and show HER2 poised to interact with other ErbB receptors in the absence of direct ligand binding.
Journal ArticleDOI
An Open-and-Shut Case? Recent Insights into the Activation of EGF/ErbB Receptors
Antony W. Burgess,Hyun Soo Cho,Hyun Soo Cho,Charles Eigenbrot,Kathryn M. Ferguson,Thomas P. J. Garrett,Thomas P. J. Garrett,Daniel J. Leahy,Mark A. Lemmon,Mark X. Sliwkowski,Colin W. Ward,Colin W. Ward,Shigeyuki Yokoyama +12 more
TL;DR: A mechanistic view of ErbB receptor homo- and heterodimerization is outlined, which suggests new approaches for interfering with these processes when they are implicated in human cancers.
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EGF Activates Its Receptor by Removing Interactions that Autoinhibit Ectodomain Dimerization
Kathryn M. Ferguson,Mitchell B. Berger,Jeannine M. Mendrola,Hyun Soo Cho,Daniel J. Leahy,Mark A. Lemmon +5 more
TL;DR: The structure reveals an autoinhibited configuration, where the dimerization interface recently identified in activated sEGFR structures is completely occluded by intramolecular interactions, which contrasts starkly with other RTK activation mechanisms and suggests new approaches for designing ErbB receptor antagonists.
Journal ArticleDOI
Structure of the Extracellular Region of HER3 Reveals an Interdomain Tether
Hyun Soo Cho,Daniel J. Leahy +1 more
TL;DR: The HER3 structure reveals a contact between domains II and IV that constrains the relative orientations of ligand-binding domains and provides a structural basis for understanding both multiple-affinity forms of EGFRs and conformational changes induced in the receptor by ligand binding during signaling.
Journal ArticleDOI
Crystal Structure of RNA Helicase from Genotype 1b Hepatitis C Virus A FEASIBLE MECHANISM OF UNWINDING DUPLEX RNA
Hyun Soo Cho,Nam-Chul Ha,Lin-Woo Kang,Kyung Min Chung,Sung Hoon Back,Sung Key Jang,Byung-Ha Oh +6 more
TL;DR: Observations suggest that some form of this dimer is likely to be the functional form that unwinds double stranded RNA processively by passing one strand of RNA through the channel and passing the other strand outside of the dimer.