G
Ginger Brechtel
Researcher at United States Department of Veterans Affairs
Publications - 24
Citations - 6947
Ginger Brechtel is an academic researcher from United States Department of Veterans Affairs. The author has contributed to research in topics: Insulin & Glucose uptake. The author has an hindex of 22, co-authored 24 publications receiving 6754 citations. Previous affiliations of Ginger Brechtel include University of California, San Diego.
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Journal ArticleDOI
Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance.
Helmut O. Steinberg,Haitham Chaker,Rosalind Leaming,Ann Johnson,Ginger Brechtel,Alain D. Baron +5 more
TL;DR: Obese/insulin-resistant subjects are characterized by endothelial dysfunction and endothelial resistance to insulin's effect on enhancement of endothelium-dependent vasodilation, which could contribute to the increased risk of atherosclerosis in obese insulin- resistant subjects.
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Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release.
TL;DR: Insulin vasodilation of skeletal muscle vasculature most likely occurs via increasing EDNO synthesis/release, and insulin appears to be a novel modulator of the EDNO system.
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Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. A novel mechanism for insulin resistance.
TL;DR: In this paper, the euglycemic clamp and leg balance techniques were used to construct the insulin dose-response curves for whole body and leg IMGU using a large range of serum insulin concentrations.
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Rates and tissue sites of non-insulin- and insulin-mediated glucose uptake in humans.
TL;DR: The results indicate that virtually all the hyperglycemia induced increment in NIMGU occurred in skeletal muscle, and the difference between overall Rd and skeletal muscle glucose uptake represents non-skeletal muscle Rd.
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Impaired Insulin-Mediated Skeletal Muscle Blood Flow in Patients With NIDDM
TL;DR: In this article, the components of skeletal muscle IMGU were studied in six obese NIDDM subjects (103 +/- 9 kg) and compared with those previously determined in six lean (weight 68 +/- 3 kg), and six obese (94 +/- 3kg) with normal glucose tolerance.