Giorgia Cordisco

TL;DR: Angiopoietin‐1 impairment is associated with angioedema, and ANGPT1 variants can be the basis of HAE.

TL;DR: Different mutations of the angiopoietin‐1 gene (ANGPT1) have been associated with the occurrence of hereditary angioedema (HAE).

TL;DR: The Italian network for C1‐INH‐HAE (ITACA) created a registry including different forms of angioedema without wheals.

TL;DR: Two novel mutations in human protein coding genes NKX2-5 and RBM20 are identified in a previously asymptomatic young man who suffered an out-of-hospital sudden cardiac arrest and an automatic implantable cardioverter defibrillator was implanted.

TL;DR: Investigation of the role of vascular endothelial growth factors A and C, angiopoietins 1 and 2, ang1/Ang2, and secretory phospholipase A2 in the pathogenesis of ACEI-AAE suggests that sartans are a safe therapeutic alternative in ACEI -AAE patients.