G
Giovanna De Chiara
Researcher at National Research Council
Publications - 36
Citations - 2107
Giovanna De Chiara is an academic researcher from National Research Council. The author has contributed to research in topics: Virus & Herpes simplex virus. The author has an hindex of 20, co-authored 31 publications receiving 1622 citations. Previous affiliations of Giovanna De Chiara include University of Rome Tor Vergata & Istituto Superiore di Sanità.
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Journal ArticleDOI
Inhibition of influenza A virus replication by resveratrol.
Anna Teresa Palamara,Lucia Nencioni,Katia Aquilano,Giovanna De Chiara,Leyanis Hernandez,Federico Cozzolino,Maria Rosa Ciriolo,Enrico Garaci +7 more
TL;DR: Investigation of the antioxidant activities of the plant polyphenol resveratrol found it strongly inhibited the replication of influenza virus in MDCK cells but that this activity was not directly related to glutathione-mediated antioxidant activity.
Journal ArticleDOI
Bcl-2 Phosphorylation by p38 MAPK: Identification of target sites and biologic consequences
Giovanna De Chiara,Maria Elena Marcocci,Maria Torcia,Maria Lucibello,Maria Lucibello,Paolo Rosini,Paolo Bonini,Yukiro Higashimoto,Gianluca Damonte,Andrea Armirotti,Sarah Amodei,Anna Teresa Palamara,Tommaso Russo,Enrico Garaci,Federico Cozzolino +14 more
TL;DR: Bcl-2 phosphorylation by activated p38 MAPK is a key event in the early induction of apoptosis under conditions of cellular stress and is obtained by using mass spectrometry techniques and specific anti-phosphopeptide antibodies.
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Infectious Agents and Neurodegeneration
Giovanna De Chiara,Maria Elena Marcocci,Rossella Sgarbanti,Livia Civitelli,Cristian Ripoli,Roberto Piacentini,Enrico Garaci,Claudio Grassi,Anna Teresa Palamara +8 more
TL;DR: This review will focus on the contribution given to neurodegeneration by herpes simplex type-1, human immunodeficiency and influenza viruses, and by Chlamydia pneumoniae.
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Recurrent herpes simplex virus-1 infection induces hallmarks of neurodegeneration and cognitive deficits in mice.
Giovanna De Chiara,Roberto Piacentini,Marco Fabiani,Alessia Mastrodonato,Maria Elena Marcocci,Dolores Limongi,Giorgia Napoletani,Virginia Protto,Paolo Coluccio,Ignacio Celestino,Domenica Donatella Li Puma,Claudio Grassi,Anna Teresa Palamara +12 more
TL;DR: Evidence is provided that mild and recurrent HSV-1 infections in the central nervous system produce an AD-like phenotype and suggest that they are a risk factor for AD.
Journal ArticleDOI
Nerve growth factor inhibits apoptosis in memory B lymphocytes via inactivation of p38 MAPK, prevention of Bcl-2 phosphorylation, and cytochrome c release.
Maria Torcia,Maria Torcia,Giovanna De Chiara,Lucia Nencioni,Serena Ammendola,Danilo Labardi,Maria Lucibello,Maria Lucibello,Paolo Rosini,Lionel N. J.L. Marlier,Paolo Bonini,Persio Dello Sbarba,Anna Teresa Palamara,Anna Teresa Palamara,Nicola Zambrano,Tommaso Russo,Enrico Garaci,Federico Cozzolino,Federico Cozzolino +18 more
TL;DR: The data demonstrate that the molecular mechanisms underlying the survival factor function of NGF critically rely upon the continuous inactivation of p38 MAPK, a Bcl-2-modifying enzyme.