Giulia Bon

TL;DR: It is demonstrated that the aberrant cytoskeleton contributes to neoplastic transformation by conferring resistance to anoikis and Restoration of stress fiber network through enhanced expression of key cytoskeletal proteins may modulate the activity of focal adhesions and sensitize the neoplastics cells to anOikis.

TL;DR: Data indicate that purified lipoaspirate-derived stem cells maintain their characteristic of staminality for a long period of in vitro culture, suggesting that they could be applied for cell-based therapy to improve autologous lipoASpirate transplant.

TL;DR: It is reported that α6β4 can regulate the expression of ErbB-3 using several different models and that the consequent formation of an ErBB-2/Erb B-3 heterodimer promotes the α6 β4-dependent activation of PI3K/Akt and the ability of this integrin to impede apoptosis of carcinoma cells.

TL;DR: Examination of human tumors revealed a significant relationship between α6β4 and ErbB-3 in P-Akt-positive and ERβ1-negative breast cancers derived from patients with lower disease free survival and evidence that both receptors are clinically relevant in predicting the response to Tamoxifen.

TL;DR: Depletion of homeodomain-interacting protein kinase 2 (HIPK2) activates beta(4) transcription that results in a strong increase ofbeta(4)-dependent mitogen-activated protein kinases and Akt phosphorylation, anchorage-independent growth, and invasion, and suggest that loss of p53 function favors the formation of coactivator complex with the TA members of the p53 family to allow beta( 4) transcription.