Giuseppa Esterina Liquori

TL;DR: The presence of a member of the aquaporin family of water channels, AQP8, is shown and the strikingly high water permeability (Pf) characterizing the rat liver IMM is demonstrated, suggesting that AQP 8-mediated water transport may be particularly important for rapid expansions of mitochondrial volume.

TL;DR: The ontogeny and exact subcellular localization of AQP8 in mouse liver, a representative organ transporting large volumes of water for secretion of bile, is defined and findings suggest an intracellular involvement of AQp8 in preserving cytoplasmic osmolality during glycogen metabolism and in maintaining mitochondrial volume.

TL;DR: The results suggest that extrahepatic cholestasis leads to downregulation of AQP9 in the hepatocyte basolateral plasma membrane and dysregulated aquaporin channels contribute to bile flow dysfunction of cholESTatic hepatocytes.

TL;DR: Water is reabsorbed from the gall‐bladder lumen during fasting, whereas it is secreted into the lumen following meal ingestion, and the molecular mechanism by which water is transported across the gall-bladder epithelium remains mostly unclear.

TL;DR: To evaluate changes in hepatocyte ultrastructure within the hepatic acinus during the liver regenerative process, light and electron microscopy observations on specimens taken 0 h, 24 h and 96 h after partial hepatectomy investigated the hepatocyte structure and ultrast structure in the periportal and pericentral area of the hepatics acinus, with a particular emphasis on mitochondria ultrast Structure.