Domenico Ferri

TL;DR: It is concluded that AQP8, AQP9, AQp3, and TIP2;1, apart from being water channels, also support significant fluxes of NH3, which could support NH4+ transport and have physiological implications for liver and kidney function.

TL;DR: The presence of a member of the aquaporin family of water channels, AQP8, is shown and the strikingly high water permeability (Pf) characterizing the rat liver IMM is demonstrated, suggesting that AQP 8-mediated water transport may be particularly important for rapid expansions of mitochondrial volume.

TL;DR: It is concluded that CD diet causes mitochondrial complex I dysfunction which can be attributed to ROS-induced cardiolipin oxidation, and new insights are provided into the alterations underlying mitochondrial dysfunction in NAFLD.

TL;DR: The ontogeny and exact subcellular localization of AQP8 in mouse liver, a representative organ transporting large volumes of water for secretion of bile, is defined and findings suggest an intracellular involvement of AQp8 in preserving cytoplasmic osmolality during glycogen metabolism and in maintaining mitochondrial volume.

TL;DR: The identity and extent of liver glycerol transport is defined and the correlation between hepatic AQP9 expression and Glycerol permeability (Pgly) in AQP 9+/+ wild‐type mice in different nutritional states and circulating insulin levels is evaluated.