G
Giuseppa Pistritto
Researcher at University of Rome Tor Vergata
Publications - 24
Citations - 1365
Giuseppa Pistritto is an academic researcher from University of Rome Tor Vergata. The author has contributed to research in topics: Cancer cell & Programmed cell death. The author has an hindex of 13, co-authored 20 publications receiving 844 citations.
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Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies
TL;DR: The role of the fundamental regulators of apoptosis are highlighted and how their deregulation, including activation of anti-apoptotic factors or inactivation of pro-ap optotic factors ends up in cancer cell resistance to therapies.
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Reactivation of mutant p53 by capsaicin, the major constituent of peppers
TL;DR: It is demonstrated for the first time that capsaicin may reduce mutant p53 levels and reactivate wild-type p53 protein in mutant p 53-carrying cells and the p53 reactivation contributes to capsaicIn-induced cell death.
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Isolation rearing-induced reduction of brain 5α-reductase expression: relevance to dopaminergic impairments.
Marco Bortolato,Marco Bortolato,Paola Devoto,Paola Roncada,Roberto Frau,Giovanna Flore,Pierluigi Saba,Giuseppa Pistritto,Alessio Soggiu,S Pisanu,Agata Zappalà,Maria Serafina Ristaldi,Maria Tattoli,Vincenzo Cuomo,Francesco Marrosu,Maria Luisa Barbaccia +15 more
TL;DR: Results show that IR induces changes in expression/activity of brain 5AR which, in a brain-region specific manner, may partially underlie the alterations in DA signaling induced by this manipulation.
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Glucose restriction induces cell death in parental but not in homeodomain-interacting protein kinase 2-depleted RKO colon cancer cells: molecular mechanisms and implications for tumor therapy.
Alessia Garufi,Alessandro Ricci,Daniela Trisciuoglio,Egidio Iorio,Giulia Carpinelli,Giuseppa Pistritto,Mara Cirone,G D′Orazi +7 more
TL;DR: It is proposed that the metabolic changes acquired by cells after HIPK2 silencing may contribute to induce resistance to cell death in glucose restriction condition, and therefore be directly relevant for tumor progression.
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Innovative Therapeutic Strategies for Cystic Fibrosis: Moving Forward to CRISPR Technique
TL;DR: In this way, CRISPR-Cas9 approach may represent a valid tool to repair the CFTR mutation and hopeful results were obtained in tissue and animal models of CF disease.