Giuseppe Boccuzzi

TL;DR: Vitamin E administration to STZ-induced diabetic rats reverses oxidative imbalance and improves muscle gene transcription, reinforcing the suggestion that oxidative stress may play a role in diabetes-related impaired muscle repair.

TL;DR: DHEA treatment, by improving oxidative balance, counteracted the enhanced AGE receptor activation and increase of profibrogenic factors and restored tissue levels of collagen I, collagen IV, and fibronectin to those of control animals, and DHEA completely restored the contractility of isolated papillary muscle.

TL;DR: Activation of the AGEs/RAGE axis, by upregulating the key enzyme for amyloid-β production, provides a pathologic link between diabetes mellitus and AD.

TL;DR: It is demonstrated that DHEA treatment clearly reduces oxidative stress products in the tissues of streptozotocin-treated rats, and protected tissues against lipid peroxidation.

TL;DR: Valproic acid (VPA), a class I selective histone deacetylase inhibitor widely used as an anticonvulsant, promotes differentiation in poorly differentiated thyroid cancer cells by inducing Na(+)/I(-) symporter and increasing iodine uptake and is also highly effective at suppressing growth.