G
Giuseppe Esposito
Researcher at Sapienza University of Rome
Publications - 187
Citations - 6047
Giuseppe Esposito is an academic researcher from Sapienza University of Rome. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 38, co-authored 117 publications receiving 4801 citations. Previous affiliations of Giuseppe Esposito include University of Naples Federico II & University of Salerno.
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Journal ArticleDOI
Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells.
Teresa Iuvone,Giuseppe Esposito,Ramona Esposito,Rita Santamaria,Massimo Di Rosa,Angelo A. Izzo +5 more
TL;DR: The results indicate that cannabidiol exerts a combination of neuroprotective, anti‐oxidative and anti‐apoptotic effects against β‐amyloid peptide toxicity, and that inhibition of caspase 3 appearance from its inactive precursor, pro‐caspase3, by cann abidiol is involved in the signalling pathway for this neuroprotection.
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Cannabidiol Reduces Aβ-Induced Neuroinflammation and Promotes Hippocampal Neurogenesis through PPARγ Involvement
Giuseppe Esposito,Caterina Scuderi,Marta Valenza,Giuseppina I. Togna,Valentina Latina,Daniele De Filippis,Mariateresa Cipriano,Maria Rosaria Carratù,Teresa Iuvone,Luca Steardo +9 more
TL;DR: Results showed that the blockade of PPARγ was able to significantly blunt CBD effects on reactive gliosis and subsequently on neuronal damage, which report the inescapable role of this receptor in mediating CBD actions.
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Cannabinoid CB1‐receptor mediated regulation of gastrointestinal motility in mice in a model of intestinal inflammation
Angelo A. Izzo,Filomena Fezza,Raffaele Capasso,Tiziana Bisogno,Luisa Pinto,Teresa Iuvone,Giuseppe Esposito,Nicola Mascolo,Vincenzo Di Marzo,Francesco Capasso +9 more
TL;DR: It is concluded that inflammation of the gut increases the potency of cannabinoid agonists possibly by ‘up‐regulating’ CB1 receptor expression; in addition, endocannabinoids, whose turnover is increased in inflamed gut, might tonically inhibit intestinal motility.
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The Spice Sage and Its Active Ingredient Rosmarinic Acid Protect PC12 Cells from Amyloid-β Peptide-Induced Neurotoxicity
TL;DR: Data show the neuroprotective effect of sage against Aβ-induced toxicity, which could validate the traditional use of this spice in the treatment of AD.
Journal ArticleDOI
Cannabidiol in vivo blunts β‐amyloid induced neuroinflammation by suppressing IL‐1β and iNOS expression
Giuseppe Esposito,Caterina Scuderi,Claudia Savani,Luca Steardo,D. De Filippis,Pietro Cottone,Teresa Iuvone,Vincenzo Cuomo +7 more
TL;DR: The present study, performed in a mouse model of AD‐related neuroinflammation, was aimed at confirming in vivo the previously reported antiinflammatory properties of CBD.