N
Nicola Mascolo
Researcher at University of Naples Federico II
Publications - 160
Citations - 8472
Nicola Mascolo is an academic researcher from University of Naples Federico II. The author has contributed to research in topics: Cannabinoid receptor & Cannabinoid. The author has an hindex of 48, co-authored 157 publications receiving 7813 citations. Previous affiliations of Nicola Mascolo include University of Salerno & Yale University.
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Flavonoids : old and new aspects of a class of natural therapeutic drugs
TL;DR: This review summarizes available data on these beneficial effects of flavonoids and suggests that the compounds may possess significant antihepatotoxic, antiallergic, anti-inflammatory, antiosteoporotic and even antitumor activities.
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Ethnopharmacologic investigation of ginger (Zingiber officinale).
TL;DR: An ethanolic extract of the rhizomes of Zingiber officinale was investigated for anti-inflammatory, analgesic, antipyretic, antimicrobial and hypoglycaemic activities in rats and rabbits and was ineffective in suppressing the writhing induced by intraperitoneal acetic acid.
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Inhibition of intestinal motility and secretion by flavonoids in mice and rats: structure-activity relationships.
G. Di Carlo,Giuseppina Autore,A. A. Izzo,P Maiolino,Nicola Mascolo,P Viola,Mv Diurno,Francesco Capasso +7 more
TL;DR: Yohimbine antagonized the inhibitory effect of flavonols (12·5–50 mg kg−1) on intraluminal accumulation of fluid and diarrhoea induced by castor oil and verapamil potentiated the flavonol effect.
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Cannabinoid CB1‐receptor mediated regulation of gastrointestinal motility in mice in a model of intestinal inflammation
Angelo A. Izzo,Filomena Fezza,Raffaele Capasso,Tiziana Bisogno,Luisa Pinto,Teresa Iuvone,Giuseppe Esposito,Nicola Mascolo,Vincenzo Di Marzo,Francesco Capasso +9 more
TL;DR: It is concluded that inflammation of the gut increases the potency of cannabinoid agonists possibly by ‘up‐regulating’ CB1 receptor expression; in addition, endocannabinoids, whose turnover is increased in inflamed gut, might tonically inhibit intestinal motility.
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Endocannabinoids as physiological regulators of colonic propulsion in mice
Luisa Pinto,Angelo A. Izzo,Maria Grazia Cascio,Tiziana Bisogno,Karen Hospodar-Scott,David R. Brown,Nicola Mascolo,Vincenzo Di Marzo,Francesco Capasso +8 more
TL;DR: Endocannabinoids acting on myenteric CB1 receptors tonically inhibit colonic propulsion in mice, and high amounts of 2-arachidonylglycerol and particularly anandamide were found in the colon, together with a high activity of an andamide amidohydrolase.