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Giuseppe Gerna
Researcher at University of Pavia
Publications - 251
Citations - 13042
Giuseppe Gerna is an academic researcher from University of Pavia. The author has contributed to research in topics: Human cytomegalovirus & Virus. The author has an hindex of 63, co-authored 249 publications receiving 12452 citations. Previous affiliations of Giuseppe Gerna include Engelhardt Institute of Molecular Biology & Georgetown University Medical Center.
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Journal ArticleDOI
Diagnosis and Management of Human Cytomegalovirus Infection in the Mother, Fetus, and Newborn Infant
TL;DR: Treatment of congenital infection with antiviral drugs is only palliative both prior to and after birth, whereas the only efficacious preventive measure seems to be the development of a safe and immunogenic vaccine, including recombinant, subunit, DNA, and peptide-based vaccines now under investigation.
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Human Cytomegalovirus UL131-128 Genes Are Indispensable for Virus Growth in Endothelial Cells and Virus Transfer to Leukocytes
Gabriele Hahn,Maria Grazia Revello,Marco Patrone,Elena Percivalle,Giulia Campanini,Antonella Sarasini,Markus Wagner,Andrea Gallina,Gabriele Milanesi,Ulrich Koszinowski,Fausto Baldanti,Giuseppe Gerna +11 more
TL;DR: It is shown here that the UL131-128 gene locus of HCMV is indispensable for both productive infection of endothelial cells and transmission to leukocytes, and suggests that a common mechanism of virus transfer may be involved in both endothelial cell tropism and leukocyte transfer.
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Isolation of human monoclonal antibodies that potently neutralize human cytomegalovirus infection by targeting different epitopes on the gH/gL/UL128-131A complex.
Annalisa Macagno,Nadia L. Bernasconi,Fabrizia Vanzetta,Erica Dander,Antonella Sarasini,Maria Grazia Revello,Giuseppe Gerna,Federica Sallusto,Antonio Lanzavecchia +8 more
TL;DR: This study describes unusually potent neutralizing antibodies against HCMV that might be used for passive immunotherapy and identifies, through the use of such antibodies, novel antigenic targets in H CMV for the design of immunogens capable of eliciting previously unknown neutralizing antibody responses.
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Infusion of autologous Epstein-Barr virus (EBV)–specific cytotoxic T cells for prevention of EBV-related lymphoproliferative disorder in solid organ transplant recipients with evidence of active virus replication
Patrizia Comoli,M. Labirio,Sabrina Basso,Fausto Baldanti,Paolo Grossi,Milena Furione,Mario Viganò,Roberto Fiocchi,Giorgio Rossi,Fabrizio Ginevri,Bruno Gridelli,Antonia Moretta,Daniela Montagna,Franco Locatelli,Giuseppe Gerna,Rita Maccario +15 more
TL;DR: The data suggest that the infusion of autologous EBV-specific CTLs obtained from peripheral blood mononuclear cells recovered at the time of viral reactivation is able to augment virus-specific immune response and to reduce viral load in organ transplant recipients.
Journal ArticleDOI
Dendritic-cell infection by human cytomegalovirus is restricted to strains carrying functional UL131-128 genes and mediates efficient viral antigen presentation to CD8+ T cells.
Giuseppe Gerna,Elena Percivalle,Daniele Lilleri,Laura Lozza,Chiara Fornara,Gabriele Hahn,Fausto Baldanti,M. Grazia Revello +7 more
TL;DR: DC infected with cell-free virus and incubated for 16 h with autologous peripheral blood mononuclear cells were found to act as a potent stimulator of both HCMV-specific CD4+- and CD8+-mediated immune responses, as determined by cytokine flow cytometry.