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Elena Percivalle
Researcher at University of Pavia
Publications - 198
Citations - 9793
Elena Percivalle is an academic researcher from University of Pavia. The author has contributed to research in topics: Human cytomegalovirus & Virus. The author has an hindex of 51, co-authored 176 publications receiving 8400 citations. Previous affiliations of Elena Percivalle include University of Milan & Mario Negri Institute for Pharmacological Research.
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Journal ArticleDOI
Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection
Karin Stettler,Martina Beltramello,Diego A. Espinosa,Victoria A. Graham,Antonino Cassotta,Antonino Cassotta,Siro Bianchi,Fabrizia Vanzetta,Andrea Minola,Stefano Jaconi,Federico Mele,Mathilde Foglierini,Mattia Pedotti,Luca Simonelli,Stuart D. Dowall,Barry Atkinson,Elena Percivalle,Cameron P. Simmons,Cameron P. Simmons,Luca Varani,Johannes Blum,Johannes Blum,Fausto Baldanti,Elisabetta Cameroni,Roger Hewson,Eva Harris,Antonio Lanzavecchia,Antonio Lanzavecchia,Federica Sallusto,Davide Corti +29 more
TL;DR: The most potent neutralizing antibodies were ZIKV-specific and targeted EDIII or quaternary epitopes on infectious virus, and an EDIII-targeted antibody protected mice against lethal infection, illustrating the potential for antibody-based therapy.
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Human Cytomegalovirus UL131-128 Genes Are Indispensable for Virus Growth in Endothelial Cells and Virus Transfer to Leukocytes
Gabriele Hahn,Maria Grazia Revello,Marco Patrone,Elena Percivalle,Giulia Campanini,Antonella Sarasini,Markus Wagner,Andrea Gallina,Gabriele Milanesi,Ulrich Koszinowski,Fausto Baldanti,Giuseppe Gerna +11 more
TL;DR: It is shown here that the UL131-128 gene locus of HCMV is indispensable for both productive infection of endothelial cells and transmission to leukocytes, and suggests that a common mechanism of virus transfer may be involved in both endothelial cell tropism and leukocyte transfer.
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Monitoring of Human Cytomegalovirus Infections and Ganciclovir Treatment in Heart Transplant Recipients by Determination of Viremia, Antigenemia, and DNAemia
G. Gerna,Donato Zipeto,M. Parea,Maria Grazia Revello,Enrico Silini,Elena Percivalle,Maurizio Zavattoni,Paolo Grossi,Gabriele Milanesi +8 more
TL;DR: Follow-up of HCMV infections in heart transplant recipients showed that PCR can detect viral appearance in blood 7-10 days earlier than assays for antigenemia/viremia, and viral disappearance from blood, as assessed by PCR, occurred weeks or months later than revealed by other assays.
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Comparison of different immunostaining techniques and monoclonal antibodies to the lower matrix phosphoprotein (pp65) for optimal quantitation of human cytomegalovirus antigenemia.
TL;DR: Comparison of the staining capabilities of three MAbs to pp65 with a commercially available MAb for determination of HCMV antigenemia showed that, while individual MAbs did not provide better results, the pool of MAbs detected a significantly higher number of positive peripheral blood polymorphonuclear leukocytes than Clonab CMV did.
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Cross-neutralization of four paramyxoviruses by a human monoclonal antibody
Davide Corti,Siro Bianchi,Fabrizia Vanzetta,Andrea Minola,Laurent Perez,Gloria Agatic,Barbara Guarino,Chiara Silacci,Jessica Marcandalli,Benjamin J. Marsland,Antonio Piralla,Elena Percivalle,Federica Sallusto,Fausto Baldanti,Antonio Lanzavecchia,Antonio Lanzavecchia +15 more
TL;DR: A human monoclonal antibody (MPE8) that potently cross-neutralizes HRSV and HMPV as well as two animal paramyxoviruses and shows potent prophylactic and therapeutic efficacy and identifies the pre-fusion F protein as a candidate H RSV vaccine.