G
Giuseppe S. Sica
Researcher at University of Rome Tor Vergata
Publications - 143
Citations - 3706
Giuseppe S. Sica is an academic researcher from University of Rome Tor Vergata. The author has contributed to research in topics: Medicine & Cancer. The author has an hindex of 30, co-authored 118 publications receiving 2738 citations.
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Journal ArticleDOI
Aryl Hydrocarbon Receptor-Induced Signals Up-regulate IL-22 Production and Inhibit Inflammation in the Gastrointestinal Tract
Ivan Monteleone,Angelamaria Rizzo,Massimiliano Sarra,Giuseppe S. Sica,Pierpaolo Sileri,Livia Biancone,Thomas T. MacDonald,Francesco Pallone,Giovanni Monteleone +8 more
TL;DR: AhR is down-regulated in intestinal tissue of patients with IBD; AhR signaling, via IL-22, inhibits inflammation and colitis in the gastrointestinal tract of mice.
Journal ArticleDOI
Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth.
V. De Simone,Eleonora Franzè,G. Ronchetti,Alfredo Colantoni,Massimo Fantini,D. Di Fusco,Giuseppe S. Sica,Pierpaolo Sileri,Thomas T. MacDonald,Francesco Pallone,Giovanni Monteleone,Carmine Stolfi +11 more
TL;DR: The data suggest that strategies aimed at the cotargeting of STAT3/NF-kB activation and interaction between them might represent an attractive and novel approach to combat CRC.
Journal ArticleDOI
European evidence based consensus on surgery for ulcerative colitis.
Tom Øresland,Willem A. Bemelman,Gianluca M. Sampietro,Antonino Spinelli,Alastair Windsor,Marc Ferrante,Philippe Marteau,Oded Zmora,Paulo Gustavo Kotze,Eloy Espin-Basany,Emmanuel Tiret,Giuseppe S. Sica,Yves Panis,Arne Engebreth Færden,Livia Biancone,Imerio Angriman,Zuzana Serclova,Anthony de Buck van Overstraeten,Paolo Gionchetti,Laurents P. S. Stassen,Janindra Warusavitarne,Michel Adamina,Axel Dignass,Rami Eliakim,Fernando Magro,André D'Hoore +25 more
TL;DR: The goal of this consensus initiated by the European Crohn's and Colitis Organisation (ECCO) was to establish European consensus guidelines for the surgical treatment of ulcerative colitis and the strategy to reach the consensus involved several steps and follows the standard operating procedures for consensus guidelines of ECCO.
Journal ArticleDOI
Autocrine regulation of IL-21 production in human T lymphocytes.
Flavio Caprioli,Massimiliano Sarra,Roberta Caruso,Carmine Stolfi,Daniele Fina,Giuseppe S. Sica,Thomas T. MacDonald,Francesco Pallone,Giovanni Monteleone +8 more
TL;DR: The existence of a positive autocrine loop that could help to amplify and stabilize IL-21-driven, T cell-mediated responses is suggested, as well as analysis of molecular mechanisms underlyingIL-21 induction, which reveals that IL- 21 activates Stat3 and enhances its recruitment to IL-20 gene promoter.
Journal ArticleDOI
Wireless capsule endoscopy and small intestine contrast ultrasonography in recurrence of Crohn's disease.
Livia Biancone,Emma Calabrese,Carmelina Petruzziello,Sara Onali,Anna Caruso,Giampiero Palmieri,Giuseppe S. Sica,Francesco Pallone +7 more
TL;DR: It is suggested that SICUS and WCE may be used as noninvasive techniques for the assessment of recurrence of CD in patients being regularly followed up after ileocolonic resection.