F
Francesco Pallone
Researcher at University of Rome Tor Vergata
Publications - 405
Citations - 19909
Francesco Pallone is an academic researcher from University of Rome Tor Vergata. The author has contributed to research in topics: Inflammatory bowel disease & Crohn's disease. The author has an hindex of 72, co-authored 405 publications receiving 18442 citations. Previous affiliations of Francesco Pallone include Queen Mary University of London & Magna Græcia University.
Papers
More filters
Journal ArticleDOI
Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7.
Massimo Fantini,Christoph Becker,Giovanni Monteleone,Francesco Pallone,Peter R. Galle,Markus F. Neurath +5 more
TL;DR: It is demonstrated that TGF-β induces a regulatory phenotype in CD4+CD25− T cells through the induction of Foxp3 and a positive autoregulatory loop of T GF-β signaling due to the absence of Smad7.
Journal ArticleDOI
Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells
Giovanni Monteleone,Livia Biancone,R. Marasco,Giovanni Morrone,O Marasco,Francesco Luzza,Francesco Pallone +6 more
TL;DR: CD LPMCs are up-regulated in their capability of releasing bioactive IL-12, and expression and release of bioactiveIL-12 seem to differentiate CD from UC.
Journal ArticleDOI
Aryl Hydrocarbon Receptor-Induced Signals Up-regulate IL-22 Production and Inhibit Inflammation in the Gastrointestinal Tract
Ivan Monteleone,Angelamaria Rizzo,Massimiliano Sarra,Giuseppe S. Sica,Pierpaolo Sileri,Livia Biancone,Thomas T. MacDonald,Francesco Pallone,Giovanni Monteleone +8 more
TL;DR: AhR is down-regulated in intestinal tissue of patients with IBD; AhR signaling, via IL-22, inhibits inflammation and colitis in the gastrointestinal tract of mice.
Journal Article
Bioactive IL-18 expression is up-regulated in Crohn's disease.
Giovanni Monteleone,Francesco Trapasso,Tiziana Parrello,Livia Biancone,Antonella Stella,Rodolfo Iuliano,Francesco Luzza,Alfredo Fusco,Francesco Pallone +8 more
TL;DR: The data indicate that IL-18 up-regulation is a feature of CD and suggest thatIL-18 may contribute to the local immunoinflammatory response in CD.
Journal ArticleDOI
Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth.
V. De Simone,Eleonora Franzè,G. Ronchetti,Alfredo Colantoni,Massimo Fantini,D. Di Fusco,Giuseppe S. Sica,Pierpaolo Sileri,Thomas T. MacDonald,Francesco Pallone,Giovanni Monteleone,Carmine Stolfi +11 more
TL;DR: The data suggest that strategies aimed at the cotargeting of STAT3/NF-kB activation and interaction between them might represent an attractive and novel approach to combat CRC.