Giuseppe Vezzoli

TL;DR: Ca excretion was higher in subjects bearing haplotypes 3, whereas those bearing haplotype 2 showed a slight increase of plasma Ca concentration, and CASR gene could be a component of the complex genetic background regulating Ca excretion.

TL;DR: A low-salt diet can reduce calcium excretion in hypercalciuric stone formers and is effective in patients affected by idiopathic calcium nephrolithiasis.

TL;DR: The findings indicate that R990G polymorphism results in a gain-of-function of the calcium-sensing receptor and increased susceptibility to primary hypercalciuria.

TL;DR: What is known about monogenic renal calcium stone-related disorders is discussed, an update on genetic research in calcium nephrolithiasis and such intermediate phenotypes as idiopathic hypercalciuria is provided, and some method tools potentially useful in this research frame of reference are proposed.

TL;DR: The findings indicate that the phospholipid arachidonic acid content anomaly could represent the primary event responsible for the mosaic of metabolic and clinical alterations that are distinctive features of renal stone formers, and suggest that a common pathogenetic mechanism might account for the several forms of hypercalciuria detected in idiopathic calcium nephrolithiasis.