Giuseppe Bianchi

TL;DR: The findings of significant linkage of the α-adducin locus to essential hypertension and greater sensitivity to changes in sodium balance among patients with the mutant allele suggest that α- adducin is associated with a salt-sensitive form of essential hypertension.

TL;DR: The results, obtained in 3–4-month-old rats, indicate that the kidneys of adult hypertensive rats are involved in the maintenance of hypertension, and may also initiate hypertension in young normotensive recipients.

TL;DR: It is shown here that one point mutation in each of two genes coding for the membrane skeleton protein adducin is associated with blood pressure in the Milan strain of rats.

TL;DR: It is shown that the adducin isoforms differentially modulate: actin assembly both in a cell-free system and within transfected cells; topography of alpha V integrin together with focal contact proteins; and Na-K pump activity at V(max) suggest a role for ad Ducin in the constitutive capacity of the epithelia both to transport ions and to expose adhesion molecules.

TL;DR: The genes encoding angiotensin converting enzyme (ACE, I/D), α-adducin (ADD, Gly460Trp) and aldosterone synthase (AS, − 344C/T) share the potential of influencing blood pressure (BP) via sodium homeostasis, but most studies in humans focused on single-gene effects and disregarded cascading effects.