Giuseppina Bozzuto

TL;DR: This review briefly analyze how the efficacy of liposomes depends on the nature of their components and their size, surface charge, and lipidic organization, and describes some strategies developed to overcome limitations of the “first-generation” liposome-based drugs on the market and in clinical trials.

TL;DR: The balance of cellular signals for proliferation and survival responses also regulates migratory behaviours of tumor cells, and the scene of crime drug resistance players can interfere thus worsening this delicate situation.

TL;DR: A link was identified between MDR transporter Pgp, and MAPK signaling and invasion, and metalloproteinase mRNAs, and proteolytic activities, which are associated with an increased invasive behavior.

TL;DR: The findings suggest that targeting CXCR4 by peptide R might represent a novel therapeutic approach against GBM, and contribute to the rationale to further explore in more complex pre-clinical settings the therapeutic potential of peptides R, alone or in combination with standard therapies of GBM.

TL;DR: Results support a critical involvement of PC-PLC in controlling molecular pathways responsible for maintaining a mesenchymal-like phenotype in metastatic BC cells and suggests PC- PLC deactivation as a means to promote BC cell differentiation and possibly enhance the effectiveness of antitumor treatments.