Marisa Colone

TL;DR: The results of this study provide the evidence that exosomes may be used as a delivery system for paracrine diffusion of tumor malignancy, in turn supporting the importance of both exosome and tumor pH as key targets for future anti-cancer strategies.

TL;DR: Data show that colorectal cancer induces T-cell apoptosis through the release of Fas ligand-bearing and tumor necrosis factor-related apoptosis-inducing ligand -bearing microvesicles both in vitro and in vivo.

TL;DR: This study reports that resting and activated NK cells, freshly isolated from blood of healthy donors, release exosomes expressing typical protein markers of NK cells and containing killer proteins, and shows that NK-derived exosome undergo uptake by tumor target cells but not by resting PBMC.

TL;DR: The study demonstrates that the isotype of anti-β-glucan antibodies may affect details of the β- glucan epitopes recognized, and this may be associated with a differing ability to inhibit virulence attributes of the fungus and confer protection in vivo.

TL;DR: Tea tree oil and terpinen-4-ol are able to impair the growth of human M14 melanoma cells and appear to be more effective on their resistant variants, which express high levels of P-glycoprotein in the plasma membrane, overcoming resistance to caspase-dependent apoptosis exerted by P- Glycoprotein-positive tumor cells.