G
Glenn K. Wakley
Researcher at Loma Linda University
Publications - 8
Citations - 1058
Glenn K. Wakley is an academic researcher from Loma Linda University. The author has contributed to research in topics: Ovariectomized rat & Bone resorption. The author has an hindex of 8, co-authored 8 publications receiving 1044 citations.
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Differential effects of androgens on cortical bone histomorphometry in gonadectomized male and female rats
TL;DR: It is demonstrated that androgens counteract the changes in cortical bone formation after gonadectomy in females as well as males, and thereby reestablish the sex difference observed in intact rats.
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Tamoxifen prevents the skeletal effects of ovarian hormone deficiency in rats
TL;DR: The findings demonstrate that in the rat, tamoxifen acts as an estrogen agonist by preventing the skeletal alterations that result from ovarian hormone deficiency.
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Tamoxifen Inhibits Osteoclast-Mediated Resorption of Trabecular Bone in Ovarian Hormone-Deficient Rats*
TL;DR: In the rat, tamoxifen mimics the effects of estrogen on trabecular bone at concentrations that are not uterotropic, and treatment of ovariectomized rats with tamoxIFen prevented these skeletal changes.
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Androgen treatment prevents loss of cancellous bone in the orchidectomized rat.
TL;DR: Because a similar protective action was achieved using the nonaromatizable androgen 5‐dihydrotestosterone, the results suggest that this bone‐sparing effect is mediated by androgen rather than by metabolism of the androgen to an estrogen.
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Dose-dependent effects of tamoxifen on long bones in growing rats: influence of ovarian status.
TL;DR: A dose response was determined for the effects of tamoxifen on bone histomorphometry in intact female and ovariectomized (OVX) rats, and results are consistent with tamoxIFen behaving as a partial estrogen agonist on rat bone.