Gong-Wen Liang

TL;DR: In conclusion, apoptotic effect is associated with deletion of intracellular Ca2+ by amlodipine through activation of caspase 8 and then 3/7 activities, which may provide a novel strategy for improving the chemotherapeutic effects.

TL;DR: The enhanced anti‐tumor effects of vincristine by quinacrine in the resistant/non‐resistant K562 cells could be because of the direct injury and the potentiating apoptotic effect of vINCristine via activating the initiator caspase‐9 and subsequently the effector caspases‐3, and the long circulatory effect of stealthy liposomes.

TL;DR: This work combined topotecan and amlodipine together into the stealthy liposomes, in which amlODipine was applied as a MDR reversing agent to overcome the resistance.

TL;DR: Results from superoxide dismutase activity, maleic dialdehyde, T-lymphocyte subsets (CD3+, CD4+, CD8+ and CD4+/CD8+ ratio) analyses suggest that all the selected enhancers improve the modulating effects of TP 5 in the immunosuppression rats.

TL;DR: Stealth liposomal topotecan plus amlodipine showed the optimal anti-tumor activity and inducing apoptotic effect in the in vivo studies, suggesting that it deserves further clinical evaluations.