G
Gonul Kanigur Sultuybek
Researcher at Istanbul Aydın University
Publications - 27
Citations - 363
Gonul Kanigur Sultuybek is an academic researcher from Istanbul Aydın University. The author has contributed to research in topics: Genotype & Metformin. The author has an hindex of 11, co-authored 27 publications receiving 271 citations. Previous affiliations of Gonul Kanigur Sultuybek include Istanbul University.
Papers
More filters
Journal ArticleDOI
NF-κB as the mediator of metformin's effect on ageing and ageing-related diseases.
TL;DR: This review underlines the pleiotropic effects of metformin in ageing and different ageing‐related diseases and attributes its effects to the modulation of NF‐kB.
Journal ArticleDOI
Polymorphism of the NFKB1 affects the serum inflammatory levels of IL-6 in Hashimoto thyroiditis in a Turkish population.
TL;DR: The findings suggest that the functional promoter NFKB1-94ins/del ATTG polymorphism was significantly associated with population HT disease through acting by directly modulating IL-6 serum levels.
Journal ArticleDOI
Association of Pre-miRNA-499 rs3746444 and Pre-miRNA-146a rs2910164 Polymorphisms and Susceptibility to Behcet's Disease
Tuba Oner,Guven Yenmis,Kubra Tombulturk,Cansu Cam,Özlem Su Küçük,Mustafa Cengiz Yakicier,Didem Dizman,Gonul Kanigur Sultuybek +7 more
TL;DR: According to genotype analysis, the frequencies of ins/ins genotype and ins allele of rs28362491 were considerably higher in BD patients, and miRNA-499 rs3746444 homozygous (TT) genotypes exibited a significantly higher ri...
Journal ArticleDOI
The protective effects of metformin in an in vitro model of aging 3T3 fibroblast under the high glucose conditions
Tugba Soydas,Elif Yaprak Sarac,Suzan Çinar,Sibel Dogan,Seyhun Solakoglu,Matem Tunçdemir,Gonul Kanigur Sultuybek +6 more
TL;DR: The data are consistent with the observation that metformin has a protective effect in this in vitro model of aging 3T3 fibroblasts under high glucose conditions inducing cell proliferation, collagen I and III production, protection from apoptosis, and reducing NF-kB(p65) activity.
Journal ArticleDOI
Association of PARP-1, NF-κB, NF-κBIA and IL-6, IL-1β and TNF-α with Graves Disease and Graves Ophthalmopathy
Mutlu Niyazoglu,Onur Baykara,Arzuhan Koc,Pinar Aydoğdu,İlhan Onaran,Fatma Dilek Dellal,Ertugrul Tasan,Gonul Kanigur Sultuybek +7 more
TL;DR: It is suggested that, PARP-1 and NFkB1 gene polymorphisms may be risk factors for developing Graves Disease and Ophthalmopathy.