Showing papers in "Gene in 2014"

TL;DR: The principles of RNA interference are described, the therapeutic potential in various diseases is reviewed and the new strategies for in vivo delivery of RNAi to overcome the challenges are discussed.

TL;DR: This paper reviews the current knowledge of the processes involved in folate metabolism and consequences of deviant folates, particular emphasis is given to the polymorphic genes which have been implicated in the development of various diseases in humans, like vascular diseases, Down's syndrome, neural tube defects, psychiatric disorders and cancers.

TL;DR: Evidence is provided that a different composition of gut microbiota in obesity and type 2 diabetes affect the epigenetic regulation of genes, and dietary interventions influencing microbial composition may be considered as an option in the engagement against metabolic syndrome.

TL;DR: Gene ontology analysis indicates that these miRNAs target transcription factors and genes that participate in several cellular pathways, including angiogenesis, cellular transport, apoptosis, and proteolysis.

TL;DR: This review addresses recent findings obtained from patients with some inherited neurometabolic diseases showing that l-carnitine may be involved in the reduction of oxidative damage observed in these disorders.

TL;DR: Diverse ways of action of lncRNAs in different sub-cellular locations are talked about and clues for following studies are provided.

TL;DR: It is suggested that circulating miR-21 may not suitable to be a diagnostic biomarker, but it has a prognostic value in patients with cancer.

TL;DR: The phenomenon of multiple isomiRs and their biological roles indicates that analysis performed at the miRNA and isomiR levels should be included in miRNA studies, and this may enrich and complicate miRNA biogenesis and coding-non-coding RNA regulatory networks.

TL;DR: This review addresses the advances and challenges in determining genetic and diagnostic markers for complex AD pathogenesis and shows that circulating microRNAs in the cerebrospinal fluid and blood serum of AD patients can be used as biomarkers in AD diagnosis.

TL;DR: It is demonstrated that miR-301a maintains constitutively activated Wnt/β-catenin signaling by directly targeting PTEN, which promotes breast cancer invasion and metastasis and is suggested to be a potential target in breast cancer therapy.

TL;DR: The experience with the use of the 105 K and 180K oligonucleotide microarrays in 215 consecutive patients referred with either autism or autism spectrum disorders or developmental delay/learning disability for genetic services at the University of Kansas Medical Center is reported.

TL;DR: Results suggest that SinfCSP19 plays a role in reception of female sex pheromones of S. inferens and host plant volatiles and that this gene was expressed in a unique profile, i.e. predominant in antennae and significantly higher in male than in female.

TL;DR: Evidence is provided that obesity influences age driven epigenetic changes, which provides a molecular link between aging and obesity, and the identified markers may prove to be valuable biomarkers for the understanding of the molecular basis of aging, obesity and associated diseases.

TL;DR: The new reference genes provided in this study are more accurate than previously reported reference genes in quantifying expression levels of B. napus and are identified to perform better than traditional reference genes ACTIN7 and GAPDH.

TL;DR: Behavioral pain assessments available for small and large experimental osteoarthritic pain animal models are described.

TL;DR: The experiments of both induced in vitro and environmental stress conditions indicate that, Sahiwal may express higher levels of Hsp90 then Frieswal to regulate their body temperature and increase cell survivality under heat stressed conditions.

TL;DR: FokI and BsmI have protective and facilitative effects on the risk for T2DM, while the ApaI genotype was associated with reduced vitamin D deficiency.

TL;DR: It can be concluded that quercetin pretreatment was protected against myocardium IR injury by decreasing oxidative stress, repressing inflammatory cascade, inhibiting apoptosis in vivo and PI3K/Akt pathway involved in the anti-apoptotic effect.

TL;DR: This article systematically introduces the basic knowledge of the HPG axis and provides information of the current advances relating to reproductive hormones.

TL;DR: Compared to wild-type (WT) plants, transgenic Arabidopsis overexpressing GmMYBJ1 exhibited an enhanced tolerance to drought and cold stresses and has the potential to be utilized in transgenic breeding lines to improve abiotic stress tolerance.

TL;DR: It is concluded that length variations of the repeats in salt responsive miRNA genes may be responsible for a possible sensitivity to salinity adaptation, the first report of characterization of trait specific miRNA derived SSRs in plants.

TL;DR: MiR-375 plays an important role in the complex regulatory network of pancreatic development, which could be regulated by pancreatic genes, such as NeuroD1, Ngn3, Pdx1 and Hnf6; additionally, miR- 375 regulates genes related to pancreas development, cell growth and proliferation and insulin secretion genes to exert its function.

TL;DR: It is confirmed here that mitogenomics is a useful tool for molluscan phylogenetics, especially when using powerful new models of amino acid evolution, but recognise that increased taxon sampling is still required to resolve existing differences between nuclear and mitochondrial gene trees.

TL;DR: This is the first study to identify hypermethylated regions across the genome in patients with coronary artery disease and further validation in different populations is necessary for this information to be used for disease risk assessment and management.

TL;DR: Evaluated expression pattern and in-silico molecular signaling pathway enrichment analysis suggest an inducing role of miR-26a in differentiation of pathogenic Th17 cells during pathogenesis of multiple sclerosis by targeting major components of the TGF-β signaling pathway and disarrangement of this signaling pathway.

TL;DR: Findings indicate that miR-375 has an important role in NSCLC initiation and progression, and may be an independent poor prognostic factor in patients with non-small cell lung cancer.

TL;DR: Results show that the expression of genes of LC-PUFA biosynthesis and cholesterol metabolism are regulated by Lxr and Srebp TFs in salmon, indicating highly conserved regulatory mechanism across vertebrates.

TL;DR: It is found that miR-26b inhibition effectively suppressed adipocyte differentiation, as evidenced by decreased lipid droplets and the ability of miR -26b to decrease mRNA levels of adipocyte-specific molecular markers and triglyceride accumulation.

TL;DR: Application of exogenous Spd could enhance salt tolerance of P. ginseng by enhancing the activities of enzyme scavenging system, which influence the intensity of oxidative stress.

TL;DR: The above results suggest that these DFR genes are associated with anthocyanin biosynthesis and cold and freezing stress tolerance and might be useful resources for development of cold and/or freezing stress resistant Brassica crops with desirable colors as well.