Gonzalo P. Solis

TL;DR: Cell-transplantation experiments indicate that the regulation of embryonic cell adhesion by PrP is cell-autonomous, and evolutionarily conserved roles of PrP in cell communication are uncovered, which ultimately impinge on the stability of adherens cell junctions during embryonic development.

TL;DR: Reggie-1 and -2 proteins form their own type of non-caveolar membrane microdomains, which are involved in important cellular processes such as T-cell activation, phagocytosis and signalling mediated by the cellular prion protein and insulin; this is consistent with the notion that reggie micro domains promote protein assemblies and signalling.

TL;DR: In this paper, a major protein component of membrane microdomains, reggie-1/flotillin-2, plays important roles in secretion and spreading of Wnt and Hedgehog in Drosophila.

TL;DR: It is shown here that reggie‐1/flotillin‐2 microdomains are organized along cortical F‐actin in several cell types and can efficiently be immobilized by actin polymerisation, while exchange of reggie-1/ Flotillin-2 molecules between micro domains is enhanced by actIn disruption as shown by tracking of individual microdomain using TIRF microscopy.

TL;DR: It is shown that reggies regulate axon regeneration in zebrafish after optic nerve section (ONS) in vivo as well as axon/neurite extension in hippocampal and N2a neurons in vitro through signal transduction molecules modulating actin dynamics.