George Hausmann

TL;DR: One focus will be the interaction of β‐catenin with different transcription factors and the potential implications of these interactions for direct cross‐talk between β‐ catenin and non‐Wnt signalling pathways.

TL;DR: The discovery of a novel Wnt pathway component, Wntless (Wls/Evi), is described and it is shown that it is required for Wingless-dependent patterning processes in Drosophila, for MOM-2-governed polarization of blastomeres in C. elegans, and for Wnt3a-mediated communication between cultured human cells.

TL;DR: These findings emphasize that β-catenin-mediated transcription affects chromatin, and how does β- catenin cope with chromatin regulation to turn on Wnt target genes?

TL;DR: This work genetically identifies a novel Wnt/Wg pathway component that mediates the transcriptional outputs of beta-catenin/Armadillo and assign to the tumor suppressor Parafibromin an unexpected role in Wnt signaling and provides a molecular mechanism for Wnt target gene control.

TL;DR: This work describes Wls accumulation in the Golgi apparatus of Wnt/Wingless (Wg)-producing cells in Drosophila, and shows that this localization is essential for Wg secretion, and indicates that Wg, clathrin-mediated endocytosis and retromer sustain a Wls Traffic Loop, thereby enabling Wls to direct Wnt secretion.