G
Gopa Biswas
Researcher at University of Delhi
Publications - 8
Citations - 86
Gopa Biswas is an academic researcher from University of Delhi. The author has contributed to research in topics: Aflatoxin & Microsome. The author has an hindex of 5, co-authored 8 publications receiving 79 citations.
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Journal ArticleDOI
Piperine, a plant alkaloid of the piper species, enhances the bioavailability of aflatoxin B1 in rat tissues.
TL;DR: Piperine-treated rat liver microsomes demonstrated a tendency to enhance [3H]AFB1 binding to calf thymus DNA in vivo and the effect of piperine on AFB1 metabolism thus closely resembles the mode of action of SKF 525-A on biotransformation of foreign compounds.
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Chemoprevention of carcinogen-DNA binding: the relative role of different oxygenated substituents on 4-methylcoumarins in the inhibition of aflatoxin B1-DNA binding in vitro
Hanumantharao G. Raj,Sangita Gupta,Gopa Biswas,Suddham Singh,Amarjit Singh,Amitabh Jha,Kirpal S. Bisht,S. K. Sharma,Subhash C. Jain,Virinder S. Parmar +9 more
TL;DR: Eighteen 4-methylcoumarins bearing methoxy/hydroxy/acetoxy functionalities have been reported to effectively inhibit the rat liver microsome-mediated aflatoxin B1-DNA binding in vitro and the results illustrate the structure-activity relationship.
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Aflatoxin B1-induced micronuclei and cell cycle alterations in lung and bone marrow cells and their modulation by Piper argyrophyllum extract
Hanumantharao G. Raj,K.C. Gupta,Viswajeet Rohil,Mridula Bose,Gopa Biswas,Sanjay K. Singh,Subhash C. Jain,Virinder S. Parmar,Carl Erik Olsen,Jesper Wengel +9 more
TL;DR: The utility of AFB1-induced Mn is proposed as a model for screening plant extracts as inhibitors of genotoxicity and for preventing genotoxic changes described above by phytochemicals is proposed.
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Comparative kinetic studies on aflatoxin B1 binding to pulmonary and hepatic DNA of rat and hamster receiving the carcinogen intratracheally
Gopa Biswas,Hanumantharao G. Raj,Amir Allameh,Manju Saxena,Narender Srivastava,K. G. Mukerji +5 more
TL;DR: The lung indicated a selective activation of AFB1 as it showed only 7.7% binding of [3H]AFB1 to pulmonary DNA, and the extent of translocated AFB1 binding to hepatic DNA presents an interesting difference from that observed when the toxin was administered through a gastrointestinal route.
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Glutathione Levels and γ-Glutamyl Transpeptidase Activities in Aflatoxigenic and Non-Aflatoxigenic Strains of Aspergillus Flavus
TL;DR: The glutathione level varied for each strain with respect to the medium, suggesting a possible role of media related factors in controlling the formation of glutathion.