Showing papers by "Graeme Nixon published in 2008"
TL;DR: It is concluded that a subpopulation of lysosomes cluster in the perinuclear region of the cell and form junctions with SR containing a high density of RyR3 to comprise a trigger zone for Ca(2+) signalling by NAADP.
98 citations
TL;DR: Despite a lack of well-defined receptor signal transduction mechanisms and sparse pharmacological data, several key characteristics of SPC are now emerging and can act as a mitogen in several different cell types and in certain circumstances, may also be a pro-inflammatory mediator.
89 citations
TL;DR: AGE can induce VSM proliferation via a prolonged agonist-induced Ca2+ increase leading to increased activation of CaN and subsequently NFATc, which may contribute to pathogenesis of vascular disease in diabetes mellitus.
24 citations
DOI•
01 Nov 2008
TL;DR: In this paper, the authors look at the evolution of RME with reference to the Curriculum for Excellence (CfE) review, with a particular focus on the increasing emergence of philosophy or philosophical methods within the subject.
Abstract: This article looks at the emergence of Philosophy within the subject variously described as Religious Education, Religious and Moral Education and Religious, Moral and Philosophical Studies. The particular context for this is provided by the proposals and guidelines published by the Curriculum for Excellence (CfE) review (March, November 2006, May 2008). The article analyses references to Philosophy in the Scottish curricular review and seeks to place these against a wider background of increasing philosophical content and approaches in RME documents since 1972. The documentary traces of the ‘philosophication’ of the subject are also mapped against definitions of Philosophy provided by academic philosophers. Introduction The intention of this paper is to look at the evolution of Religious and Moral Education (henceforth RME, unless discussing Scottish Higher Still Qualifications in which case the acronym RMPS will be used) with reference to ‘A Curriculum for Excellence’ (CfE) review, with a particular focus on the increasing emergence of philosophy or philosophical methods within the subject. This allows us to take stock of developments in this subject area and assess the vision of RME outlined in the Curriculum Review against the reality of what has been stated in curricular guidelines and key documents in the development of RME. At the time of writing (June 2008) the teaching profession is being asked to evaluate the newly published draft outcomes for RME with a view to the creation of a final document for use in schools in 2009. It is therefore with this in mind that this article seeks to raise awareness that RME in Scotland is a subject that has undergone profound change over the last 38 years, both in terms of methodology and content. Central to these changes has been the move away from confessional religious instruction towards a faith neutral philosophical approach. Key documents in the history and development of RME are considered and cross referenced for philosophical content and methods with definitions of Philosophy from
6 citations