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Grazia Esposito
Researcher at Seconda Università degli Studi di Napoli
Publications - 26
Citations - 895
Grazia Esposito is an academic researcher from Seconda Università degli Studi di Napoli. The author has contributed to research in topics: Mesenchymal stem cell & Cardiotoxicity. The author has an hindex of 14, co-authored 23 publications receiving 727 citations.
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Journal ArticleDOI
Doxorubicin induces senescence and impairs function of human cardiac progenitor cells
Elena Piegari,Antonella De Angelis,Donato Cappetta,Rosa Russo,Grazia Esposito,Sarah Costantino,Gallia Graiani,Caterina Frati,Lucia Prezioso,Liberato Berrino,Konrad Urbanek,Federico Quaini,Francesco Rossi +12 more
TL;DR: Premature senescence of hCPCs and their progeny can be responsible for the decline in the regenerative capacity of the heart and may represent the cellular basis of DOXO-induced cardiomyopathy in humans.
Journal ArticleDOI
HMGB1 Attenuates Cardiac Remodelling in the Failing Heart via Enhanced Cardiac Regeneration and miR-206- Mediated Inhibition of TIMP-3
Federica Limana,Grazia Esposito,Daniela D'Arcangelo,Anna Di Carlo,Sveva Romani,Guido Melillo,Antonella Mangoni,Chiara Bertolami,Giulio Pompilio,Antonia Germani,Maurizio C. Capogrossi +10 more
TL;DR: HMGB1 injected into chronically failing hearts enhanced LV function and attenuated LV remodelling; these effects were associated with cardiac regeneration, increased collagenolytic activity, miR-206 overexpression and miR -mediated inhibition of TIMP-3.
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SIRT1 activation attenuates diastolic dysfunction by reducing cardiac fibrosis in a model of anthracycline cardiomyopathy.
Donato Cappetta,Grazia Esposito,Elena Piegari,Rosa Russo,Loreta Pia Ciuffreda,Alessia Rivellino,Liberato Berrino,Francesco Rossi,Antonella De Angelis,Konrad Urbanek +9 more
TL;DR: SIRT1 activation by interfering with fibrogenesis can improve relaxation properties of myocardium and attenuate myocardial remodeling related to chemotherapy and reveal a key role of SIRT1 in supporting animal survival and functional parameters of the heart.
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Effects of ranolazine in a model of doxorubicin-induced left ventricle diastolic dysfunction.
Donato Cappetta,Grazia Esposito,Raffaele Coppini,Elena Piegari,Rosa Russo,Loreta Pia Ciuffreda,Alessia Rivellino,Lorenzo Santini,Concetta Rafaniello,Cristina Scavone,Francesco Rossi,Liberato Berrino,Konrad Urbanek,Antonella De Angelis +13 more
TL;DR: This study tested whether the administration of ranolazine, a selective blocker of late Na+ current, immediately after completing doxorubicin therapy, could affect diastolic dysfunction and interfere with the progression of functional decline.
Journal ArticleDOI
MicroRNA-34a regulates doxorubicin-induced cardiotoxicity in rat
Elena Piegari,Rosa Russo,Donato Cappetta,Grazia Esposito,Konrad Urbanek,Carmela Dell'Aversana,Lucia Altucci,Liberato Berrino,Francesco Rossi,Antonella De Angelis +9 more
TL;DR: The silencing of miR-34a could represent a future therapeutic option for cardioprotection in DOXO toxicity and at the same time, it could be considered as a circulating biomarker for anthracycline-induced cardiac damage.