Greg Conn

TL;DR: Glioma-derived vascular endothelial cell growth factor (GD-VEGF) is a 46-kDa dimeric glycoprotein mitogen with apparently greater specificity for vascular endothelium cells than the well-characterized fibroblast growth factors.

TL;DR: The existence of not only homodimer but also heterodimers clearly extends the similarity between the VEGF/PlGF and the homologous platelet-derived growth factor systems.

TL;DR: A growth factor that is mitogenic for vascular endothelial cells, with an ED50 of approximately 1 ng/ml, has been purified 170,000-fold to apparent homogeneity from tissue culture medium conditioned by a rat glioma-derived cell line, suggesting that this secretable growth factor could be readily available in the extracellular space under normal physiological conditions in vivo.

TL;DR: In this paper , the combination of checkpoint inhibitor (CPI) and pembrolizumab is shown to be safe and well tolerated without evidence of enhanced or significant toxicity.

TL;DR: Gandhapudi et al. as mentioned in this paper used the enantiomeric cationic lipid R-DOTAP nanoparticle platform (Versamune®) to promote cross presentation of multi-epitope human papilloma virus (HPV) antigens and upregulation of Type I interferons, leading to high levels of antigen-specific cytolytic polyfuctional CD8+ T-cells in vivo and complete regression of TC-1 tumors in preclinical models.