Marie-Therese Schaeffer

TL;DR: A growth factor that is mitogenic for vascular endothelial cells, with an ED50 of approximately 1 ng/ml, has been purified 170,000-fold to apparent homogeneity from tissue culture medium conditioned by a rat glioma-derived cell line, suggesting that this secretable growth factor could be readily available in the extracellular space under normal physiological conditions in vivo.

TL;DR: This cysteine-mediated destabilization of aFGF not only diminishes its activity in the absence of heparin in tissue culture but also could functionally restrict itsActivity in vivo to the vicinity of mast cell-derived heparins and heparan proteoglycans associated with cell surfaces and basement membranes.

TL;DR: Results indicate that the sequence variation in the E3 loop is responsible for the species difference between rat and human BRS-3, and multiple residues in theE3 loop are involved in interactions with the agonist dY-bombesin.

TL;DR: It is found that site-directed mutants in which any one of these Cys residues is converted to serine remain highly active, although variably dependent on heparin, so none of the three possible intramolecular disulfide bonds that can be formed are required for mitogenic activity.

TL;DR: The two amide derivatives 24a and b (hCB1 IC50 = 6.1 and 4.0 nM) demonstrated efficacy in overnight feeding studies in the rat for reduction in both food intake and overall body weight.