Gregg D. Jongeward

TL;DR: The sli-1 gene is a negative regulator of LET-23 and is shown here to encode a protein similar to c-Cbl, a mammalian proto-oncoprotein, which may define a new class of proteins that modify receptor tyrosine kinase-mediated signal transduction.

TL;DR: It is proposed that sli-1 is a negative regulator that acts at or near the LET-23-mediated step of the vulval induction pathway, and suggests that let-23 can activate distinct signaling pathways in different tissues: one pathway is required for vulv induction; another pathway is involved in hermaphrodite fertility and is not regulated by slo-1.

TL;DR: Cloned unc-101 is cloned and found that it encodes a homolog of the mammalian medium chains of clathrin-associated protein complexes located at the trans-Golgi and the plasma membrane, AP47 and AP50, respectively, which might contribute to the negative regulation of vulval differentiation.

TL;DR: A subset of the mutations reported here represents the first single missense mutations that have been demonstrated to significantly block mitochondrial protein import in vivo, and provides support for mitochondrialprotein import models in which both the structure and charge of the import signal play a critical role in directing mitochondrial protein targeting and import.

TL;DR: This work has characterized genes that negatively regulate this inductive signaling pathway and found that such negative regulators are functionally redundant: mutation of only one of these negative regulators has no effect on vulval differentiation; however, if particular combinations of these genes are inactivated, excessive vulval differentiated occurs.