Gregory Duncombe

TL;DR: While the functional significance of placental exosomes in pregnancy remains to be fully elucidated, available data support a role in normal placental development and maternal immunotolerance and the application of specific and well-characterized isolation methodologies is requisite to resolving the precise role of exosome in complications of pregnancies and their ultimate clinical utility.

TL;DR: Exosomes isolated from GDM pregnancies significantly increased the release of proinflammatory cytokines from endothelial cells, and exosome profiles may be of diagnostic utility for screening asymptomatic populations.

TL;DR: In this article, a retrospective review was performed of all cases since 1995 with a prenatal diagnosis of fetal cystic adenomatoid malformation of the lung (CCAM) from the sole tertiary perinatal referral center in Western Australia.

TL;DR: The effects of high glucose on exosomes bioactivity may be recapitulated in vivo and is of clinical relevance in association with maternal insulin resistance and preeclampsia (associated with placental insufficiency and hypoxia).

TL;DR: Endoscopic laser ablation of placental anastomoses has become the primary treatment modality, supported by a randomised trial showing improved survival and short but not long-term neurological morbidity, and comparative pre- and post-laser studies, which provide considerable insight into the pathophysiology.