Sebastian E. Illanes

TL;DR: The number of exosomes present in the maternal plasma increased significantly with gestational age across the first trimester of pregnancy, and this study is a baseline that provides an ideal starting point for developing early detection method for women who subsequently develop pregnancy complications.

TL;DR: Changes in exosome profile may be of clinical utility in the diagnosis of placental dysfunction because pregnancy is associated with a dramatic increase in the number of exosomes present in plasma and maternal plasmaExosomes are bioactive.

TL;DR: While the functional significance of placental exosomes in pregnancy remains to be fully elucidated, available data support a role in normal placental development and maternal immunotolerance and the application of specific and well-characterized isolation methodologies is requisite to resolving the precise role of exosome in complications of pregnancies and their ultimate clinical utility.

TL;DR: Exosomes isolated from GDM pregnancies significantly increased the release of proinflammatory cytokines from endothelial cells, and exosome profiles may be of diagnostic utility for screening asymptomatic populations.

TL;DR: It is suggested that the concentration and content of exosomes may be of diagnostic utility for women at risk for developing preeclampsia, in presymptomatic women who subsequently developed PE.