G
Gregory L. Beutner
Researcher at Bristol-Myers Squibb
Publications - 79
Citations - 3642
Gregory L. Beutner is an academic researcher from Bristol-Myers Squibb. The author has contributed to research in topics: Lewis acids and bases & Catalysis. The author has an hindex of 23, co-authored 74 publications receiving 3207 citations. Previous affiliations of Gregory L. Beutner include Sirna Therapeutics & California Institute of Technology.
Papers
More filters
Journal ArticleDOI
Lewis Base Catalysis in Organic Synthesis
TL;DR: It has become increasingly apparent that the behavior of Lewis bases as agents for promoting chemical reactions is not merely as an electronic complement of the cognate Lewis acids: in fact Lewis bases are capable of enhancing both the electrophilic and nucleophilic character of molecules to which they are bound.
Journal ArticleDOI
Catalytic, Enantioselective, Vinylogous Aldol Reactions
TL;DR: The current scope and limitations of this vinylogous extension to the aldol reaction, as well as its application in natural product synthesis, are discussed.
Journal ArticleDOI
Lewis‐Base‐Katalyse in der organischen Synthese
Journal ArticleDOI
Hindered dialkyl ether synthesis with electrogenerated carbocations
Jinbao Xiang,Jinbao Xiang,Ming Shang,Yu Kawamata,Helena Lundberg,Helena Lundberg,Solomon H. Reisberg,Miao Chen,Pavel K. Mykhailiuk,Pavel K. Mykhailiuk,Pavel K. Mykhailiuk,Gregory L. Beutner,Michael R. Collins,Alyn Davies,Matthew Del Bel,Gary M. Gallego,Jillian E. Spangler,Jeremy T. Starr,Shouliang Yang,Donna G. Blackmond,Phil S. Baran +20 more
TL;DR: A route to the synthesis of hindered ethers is developed, in which electrochemical oxidation is used to liberate high-energy carbocations that are then captured by an alcohol that enables the formation of a range of ethers that would otherwise be difficult to access.
Journal ArticleDOI
Lewis base activation of Lewis acids: catalytic, enantioselective addition of silyl ketene acetals to aldehydes.
TL;DR: The high levels of regio-, anti diastereo-, and enantioselectivity observed in these reactions can be rationalized through consideration of an open transition structure where steric interactions between the silyl cation complex and the approaching nucleophile are dominant.