G
Gregory M. Nelson
Researcher at Brigham Young University
Publications - 16
Citations - 436
Gregory M. Nelson is an academic researcher from Brigham Young University. The author has contributed to research in topics: Lymphatic system & Computer science. The author has an hindex of 9, co-authored 13 publications receiving 393 citations. Previous affiliations of Gregory M. Nelson include Harvard University & Mayo Clinic.
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Journal ArticleDOI
Endothelial Nitric Oxide Synthase Mediates Lymphangiogenesis and Lymphatic Metastasis
Johanna Lahdenranta,Jeroen Hagendoorn,Timothy P. Padera,Tohru Hoshida,Gregory M. Nelson,Satoshi Kashiwagi,Rakesh K. Jain,Dai Fukumura +7 more
TL;DR: It is shown that genetic deletion of eNOS as well as NOS blockade attenuates peritumor lymphatic hyperplasia of VEGF-C-overexpressing T241 fibrosarcomas and decreases the delivery of metastatic tumor cells to the draining lymph nodes, and the correlation between NOS and lymphatic metastasis is explained.
Journal ArticleDOI
Multiple domains of the co-chaperone Hop are important for Hsp70 binding.
Patricia E. Carrigan,Gregory M. Nelson,Patricia J. Roberts,Jha'Nae Stoffer,Daniel L. Riggs,David F. Smith +5 more
TL;DR: Surprisingly, truncation of EEVD plus as many as 34 additional amino acids from the Hsp70 C terminus did not reduce the ability of HSp70 mutants to co-immunoprecipitate with Hop, although further truncation eliminated Hop binding.
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Differential gene expression of primary cultured lymphatic and blood vascular endothelial cells.
TL;DR: This work has identified new molecules that are associated with BECs and LECs that may lead to novel therapeutic treatments for diseases of lymphatic or blood vessels, including metastasis of cancer to lymph nodes or distant organs.
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The heat shock protein 70 cochaperone hip enhances functional maturation of glucocorticoid receptor.
Gregory M. Nelson,Viravan Prapapanich,Patricia E. Carrigan,Patricia J. Roberts,Daniel L. Riggs,David F. Smith +5 more
TL;DR: Hip functions by a previously unrecognized mechanism to promote the efficiency of GR maturation in cells and is not critical for boosting GR responsiveness to hormone.
Journal ArticleDOI
Comparison of the carboxy-terminal DP-repeat region in the co-chaperones Hop and Hip
TL;DR: It is reported here that the DP repeat lies within a protease-resistant domain that extends to or is near the C-terminus of both co-chaperones.